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Adv Pharm Bull. 2012;2(2): 233-237.
doi: 10.5681/apb.2012.035
PMID: 24312798
PMCID: PMC3845989
Scopus ID: 84875912157
  Abstract View: 939
  PDF Download: 770

Original Research

Association between Thrombophilia and Repeated Assisted Reproductive Technology Failures

Kobra Hamdi, Maryam Vaezi, Behrooz Dagigazar, Mahzad Mehrzad Sadagiani, Laya Farzadi, Maryam Pashaei-Asl*
*Corresponding Author: Email: Pashaimaryam@yahoo.com

Abstract

Purpose: This study was performed to investigate the incidence of thrombophilic gene mutations in repeated assisted reproductive technology (ART) failures. Methods: The prevalence of mutated genes in the patients with a history of three or more previous ART failures was compared with the patients with a history of successful pregnancy following ARTs. The study group included 70 patients, 34 with three or more previously failed ARTs (A) and control group consisted of 36 patients with successful pregnancy following ARTs (B). All patients were tested for the presence of mutated thrombophilic genes including factor V Leiden (FVL), Methylenetetrahydrofolate reductase (MTHFR) and Prothrombin (G20210A) using real-time polymerase chain reaction (RT- PCR). Results: Mutation of FVL gene was detected in 5.9% women of group A (2 of 34) compared with 2.8% women (1 of 36) of control group (P = 0.6). Mutation of MTHFR gene was found in 35.3% (12 cases) as compared with 50% (18 cases) of control (35.3% versus 50%; P = 0.23). Regarding Prothrombin, only control group had 5.6% mutation (P = 0.49). No significant differences were detected in the incidences of FVL, Prothrombin and MTHFR in the study group A compared with the control group B. Conclusion: The obtained results suggest that thrombophilia does not have a significant effect in ART failures.
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Submitted: 15 Aug 2012
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