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Adv Pharm Bull. 2013;3(1): 127-130.
doi: 10.5681/apb.2013.021
PMID: 24312824
PMCID: PMC3846029
Scopus ID: 84874961915
  Abstract View: 1129
  PDF Download: 1273

Original Research

Comparison of Inhibitory Effect of Curcumin Nanoparticles and Free Curcumin in Human Telomerase Reverse Transcriptase Gene Expression in Breast Cancer

Fatemeh kazemi-Lomedasht, Abbas Rami, Nosratolla Zarghami *

Abstract

Purpose: Telomerase is expressed in most cancers, including breast cancer. Curcumin, a polyphenolic compound that obtained from the herb of Curcuma longa, has many anticancer effects. But, its effect is low due to poor water solubility. In order to improve its solubility and drug delivery, we have utilized a ß-cyclodextrin-curcumin inclusion complex. Methods: To evaluate cytotoxic effects of cyclodextrin-curcumin and free curcumin, MTT assay was done. Cells were treated with equal concentration of cyclodextrin-curcumin and free curcumin. Telomerase gene expression level in two groups was compared by Real-time PCR. Results: MTT assay demonstrated that ß-cyclodextrin-curcumin enhanced curcumin delivery in T47D breast cancer cells. The level of telomerase gene expression in cells treated with cyclodextrin-curcumin was lower than that of cells treated with free curcumin (P=0.001). Conclusion: Results are suggesting that cyclodextrin-curcumin complex can be more effective than free curcumin in inhibition of telomerase expression.
Keywords: Anti cancer drug, Target therapy, Telomerase, Breast cancer, Drug delivery
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Submitted: 06 Oct 2012
Revision: 30 Oct 2012
ePublished: 07 Feb 2013
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