Adv Pharm Bull. 2014;4(3): 283-287.
doi: 10.5681/apb.2014.041
PMID: 24754013
PMCID: PMC3992965
Scopus ID: 84983580833
  Abstract View: 2151
  PDF Download: 2502

Original Research

Thermal Analysis Study of Antihypertensive Drugs Telmisartan and Cilazapril

Refaat Ahmed Saber 1*, Ali Kamal Attia 2, Waheed Mohamed Salem 2

1 Faculty of Technology and Development, Zagazig University, Egypt.
2 National Organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt.


Purpose: The aim of the present work is to study the thermal analysis of telmisartan and cilazapril. Methods: Thermogravimetry (TGA), derivative thermogravimetry (DTG) and differential thermal analysis (DTA) were used through the work to achieve the thermal analysis study of some antihypertensive drugs, telmisartan and cilazapril. Results: The results led to thermal stability data and also to the interpretation concerning the thermal decomposition. Thermogravimetry data allowed determination of the kinetic parameters such as, activation energy and frequency factor. Conclusion: The simplicity, speed and low operational costs of thermal analysis justify its application in the quality control of pharmaceutical compounds for medications.
Keywords: Telmisartan, Cilazapril, Antihypertensive, Drugs, Quality control, Thermal analysis
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Submitted: 08 Sep 2013
Revision: 31 Dec 2013
ePublished: 07 Feb 2014
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