Abstract
Purpose: A new sensitive sensor was fabricated for the
determination of ivabradine hydrochloride (IH)
based on modification with multiwalled carbon nanotubes using sodium dodecyl sulfate as micellar medium to increase
the sensitivity.
Methods: The electrochemical behavior of IH was studied in Britton-Robinson buffer (pH: 2.0-11.0) using cyclic
and differential pulse voltammetry.
Results: The voltammetric response was linear over the range
of 3.984 x 10-6-3.475 x 10-5 mol L-1. The
limits of detection and quantification were found to be 5.160 x 10-7 and
1.720 x 10-6 mol L-1, respectively.
Conclusion: This method is suitable for determination of IH in
tablets and plasma.