Abstract
Purpose:
Thermal analysis techniques have been applied to study the thermal behavior of fenbendazole
(Fen) and rafoxanide (Raf). Semi-empirical molecular orbital calculations were
used to confirm these results.
Methods: Thermogravimetric analysis,
derivative thermogravimetry, differential thermal analysis and differential
scanning calorimetry were used to determine the thermal behavior and purity of
the drugs under investigation.
Results: Thermal behavior of Fen and Raf were augmented using semi-empirical molecular orbital calculations. The purity values were found to be 99.17% and
99.60% for Fen and Raf, respectively.
Conclusion: Thermal analysis techniques gave satisfactory results
to obtain quality control parameters such as melting point and degree of purity
at low cost, furthermore, its simplicity and sensitivity justifies its
application in quality control laboratories.