Abstract
Purpose: A Multiparticulate
system of Mebendazole was developed for colon targeted drug delivery by using
natural polysaccharides like Chitosan and Sodium-alginate beads.
Methods: Chitosan
microspheres were formulated by using Emulsion crosslinking method using Glutaraldehyde
as crosslinking agent. Sodium-alginate beads were formulated by using Calcium
chloride as gelling agent. Optimization for Chitosan microspheres was carried
out by using 23 full factorial design. 32 full factorial
design was used for the optimization of Sodium-alginate beads. The formulated
batches were evaluated for percentage yield, particle size measurement, flow
properties, percent entrapment efficiency, Swelling studies. The formulations
were subjected to Stability studies and In-vitro release study (with and
without rat caecal content). Release kinetics data was subjected to different
dissolution models.
Results: The
formulated batches showed acceptable particle size range as well as excellent
flow properties. Entrapment efficiency for optimized batches of Chitosan
microspheres and sodium alginate beads was found to be 74.18% and 88.48%
respectively. In-vitro release of drug for the optimized batches was found to
be increased in presence of rat caecal content. The best-fit models were koresmeyer-peppas
for Chitosan microspheres and zero order for sodium-alginate beads.
Conclusion: Chitosan and
Sodium-alginate was used successfully for the formulation of Colon targeted
Multiparticulate system.