Abstract
Purpose: In the present study, we have formulated zaltoprofen
loaded, surface decorated, biodegradable gelatin nanogel and evaluated its
texture characterization.
Methods: The method used to prepare gelatin
nanoparticles (GNP) was ‘two step desolvation’ and its surface decoration was
performed with oleic acid (OA). The GNP was optimized by DOE software. Nanogels
were evaluated for particle size entrapment efficiency, texture properties,
SEM, in-vitro, ex-vivo drug release studies, in-vitro
characterization, stability and in vivo
evaluation of nanogel for anti-inflammatory activity was carried out by
carrageenan induced rat paw edema method as an anti-inflammatory experimental
model.
Results: The formulated GNP with particle size and
entrapment efficiency of optimized batch was found to be 247.1 nm and 76.21%
respectively. The SEM of GNP shows smooth and spherical shape. In-vitro and Ex-vivo
drug release shows that there was 69.47% and 78.59% drug released within 48
hrs. It follows Ritger
peppas model, which indicates sustained drug release. The good texture properties
of nanogel were observed from texture analysis graphs.In vivo studies of our
formulation give significant results compared to the marketed nanogel.
Stability data revealed stability of nanogel formulation up to 3 months.
Conclusion: The present approach can provide us promising results
of the sustained analgesic activity and the stability of drug within the GNP.