Adv Pharm Bull. 2014;4(1):5-13.
doi: 10.5681/apb.2014.002
PMID: 24409403
PMCID: PMC3885369
Scopus id: 84892467787
  Abstract View: 688
  PDF Download: 1535

Reviews

Immunomodulatory Nature and Site Specific Affinity of Mesenchymal Stem Cells: a Hope in Cell Therapy

Parisa Lotfinegad 1, karim Shamsasenjan 2 * , Aliakbar Movassaghpour 3, Jafar Majidi 1, Behzad Baradaran 1

1 Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran.
2 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tabriz, Iran.
3 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Immunosuppressive ability of mesenchymal stem cells (MSCs), their differentiation properties to various specialized tissue types, ease of in vitro and in vivo expansion and specific migration capacity, make them to be tested in different clinical trials for the treatment of various diseases. The immunomodulatory effects of MSCs are less identified which probably has high clinically significance. The clinical trials based on primary research will cause better understanding the ability of MSCs in immunomodulatory applications and site specific migration in the optimization of therapy. So, this review focus on MSCs functional role in modulating immune responses, their ability in homing to tumor, their potency as delivery vehicle and their medical importance.
First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 688

Your browser does not support the canvas element.


PDF Downloaded: 1535

Your browser does not support the canvas element.

Submitted: 15 Aug 2013
Revised: 05 Sep 2013
First published online: 23 Dec 2013
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)