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Adv Pharm Bull. 2014;4(1): 5-13.
doi: 10.5681/apb.2014.002
PMID: 24409403
PMCID: PMC3885369
Scopus ID: 84892467787
  Abstract View: 1155
  PDF Download: 1899

Reviews

Immunomodulatory Nature and Site Specific Affinity of Mesenchymal Stem Cells: a Hope in Cell Therapy

Parisa Lotfinegad 1, karim Shamsasenjan 2 * , Aliakbar Movassaghpour 3, Jafar Majidi 1, Behzad Baradaran 1

1 Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran.
2 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tabriz, Iran.
3 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Immunosuppressive ability of mesenchymal stem cells (MSCs), their differentiation properties to various specialized tissue types, ease of in vitro and in vivo expansion and specific migration capacity, make them to be tested in different clinical trials for the treatment of various diseases. The immunomodulatory effects of MSCs are less identified which probably has high clinically significance. The clinical trials based on primary research will cause better understanding the ability of MSCs in immunomodulatory applications and site specific migration in the optimization of therapy. So, this review focus on MSCs functional role in modulating immune responses, their ability in homing to tumor, their potency as delivery vehicle and their medical importance.
Keywords: Mesenchymal stem cells, Immunomodulation, Cell migration, Cell therapy
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Submitted: 15 Aug 2013
Revision: 05 Sep 2013
ePublished: 23 Dec 2013
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