Mohammad Ali Behnam
1, Farzin Emami
1, Zahra Sobhani
2*, Omid Koohi-Hosseinabadi
3, Amir Reza Dehghanian
4, Seyed Mojtaba Zebarjad
5, Mohammad Hadi Moghim
5, Ahmad Oryan
61 Nano Opto-Electronic Research Center, Electrical and Electronics Engineering Department, Shiraz University of Technology, Shiraz, Iran
2 Quality Control Department, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
3 Center of Experimental and Comparative Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
4 Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
5 Materials Science and Engineering Department, Engineering School, Shiraz University, Shiraz, Iran.
6 Pathology Department, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Abstract
Purpose: Plasmonic photo
thermal therapy (PPTT) is a therapeutic method in which the photon energy is
rapidly transformed into heat via a series of radiative and non-radiative
phenomena to ablate cancer. Plasmonic NPs, such as silver NPs (Ag NPs), have
considerable properties in optical absorbance. Furthermore, good thermal
conductivity and cell penetration ability of carbon nanotubes (CNTs) could
improve the efficacy of Ag NPs for PPTT. Decoration of the multi-walled carbon
nanotubes (MWCNTs) with silver has been developed to enhance thermal
conductivity of the MWCNT particles.
Methods: The Ag NPs were
decorated on the CNTs and the ability of these particles (CNT/Ag NPs) in
reduction of melanoma tumor size after PTT was evaluated experimentally. For
comparison, the PTT of silver nanorods (Ag NRs) and CNTs were investigated. The
melanoma tumor was induced by injection of B16/F10 cell line to the inbred
mice. Different NPs were injected into the tumors and then irradiated via laser
diode (λ=670 nm, P=500 mW, and I= 3.5 W/cm2) at scheduled time.
Results: Monitoring of tumor
sizes showed that integration of CNTs with silver could enhance the optical
absorption of CNTs and improve tumor destruction in PPTT technique.
Conclusion: The
CNT/Ag NPs could act as a potent agent in PPTT method in curing solid tumors.