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Adv Pharm Bull. 2018;8(2): 347-351.
doi: 10.15171/apb.2018.040
PMID: 30023337
PMCID: PMC6046431
Scopus ID: 85048896288
  Abstract View: 2329
  PDF Download: 1163

Short Communication

Effect of Cucurbita Maxima on Control of Blood Glucose in Diabetic Critically Ill Patients

Ata Mahmoodpoor 1, Mahsa Medghalchi 2, Hossein Nazemiyeh 3,4, Parina Asgharian 5,4, Kamran Shadvar 6, Hadi Hamishehkar 7*

1 Department of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Iranian Evidence Based Medicine Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
5 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
6 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
7 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
*Corresponding Author: Email: hamishehkar@gmail.com

Abstract

Purpose: Cucurbita maxima Duchense (C. maxima) has been widely used in China and Mexico as a hypoglycemic plant for controlling blood glucose in diabetic patients. Furthermore, in northwest of Iran, this plant is used traditionally for controlling of diabetes. We examined the effect of C. maxima pulp besides insulin on control of hyperglycemia in diabetic patients admitted to Intensive care unit (ICU). Methods: Twenty critically ill patients who were admitted to the ICU were enrolled in this study. 5g lyophilized powder of C. maxima was administrated every 12 hours for 3 days. Moreover, blood glucose level and insulin dose were measured every 1-4 hours during 3 days before administration and 3days at the time of C. maxima administration. Results: The average of glucose level in 3 days before C. maxima administration was 214.9 ± 55.7 mg/dl, while in 3 days during C. maxima administration it was decreased to 178.4 ± 36.1 mg/dl (P<0.001). Additionally, the average insulin dose during 3 days before intervention was 48.05 ± 36.5 IU and during the 3 days of C. maxima administration was decreased to 39.5 ± 27.8 IU (P=0.06). Conclusion: It seems that C. maxima may decrease high blood glucose level fast and effective in diabetic critically ill patients.
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Submitted: 14 Jan 2018
Revision: 01 Apr 2018
Accepted: 11 Apr 2018
ePublished: 19 Jun 2018
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