Logo-apb
Adv Pharm Bull. 2018;8(3): 401-410.
doi: 10.15171/apb.2018.047
PMID: 30276136
PMCID: PMC6156487
Scopus ID: 85052553038
  Abstract View: 4025
  PDF Download: 1294

Research Article

Comparison of Pectin Layers for Nicotine Transdermal Patch Preparation

Jirapornchai Suksaeree 1* ORCID logo, Jessada Prasomkij 1, Kamon Panrat 2, Wiwat Pichayakorn 3

1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rangsit University, Muang, Pathum Thani 12000, Thailand.
2 Pharmaceutical Laboratory Service Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
3 Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
*Corresponding Author: Email: jirapornchai.s@rsu.ac.th

Abstract

Purpose: The objective of the present investigation was to prepare and evaluate transdermal patches for nicotine. Methods: Pectin isolated from the hulls of Monthong durian or leaves of Krueo Ma Noy was used as a matrix membrane for the controlled release of nicotine and compared with commercial pectin. The mechanical properties, moisture uptake, and Fourier transform infrared spectra were characterized. The in vitro stability of these patches was evaluated and compared to commercial nicotine patches. Results: The mechanical properties of the patches made from isolated pectin were greater than those prepared from commercial pectin; brittle commercial patches were obtained after nicotine loading. The moisture uptake of the patches made with isolated pectin was in the range of 30.20-44.29%. There was no incompatibility between the ingredients of the nicotine transdermal patches or any degradation of the drug. The matrix layer made from isolated pectin controlled the nicotine release more effectively than did commercial nicotine patches. In addition, these patches were stable at in a refrigerator (approximately 4±2 °C) and at ambient temperature (approximately 30±2 °C) for 3 months, retaining 90% of the loaded nicotine. Conclusion: Our study suggests that using isolated pectin as the matrix layer should control the release of nicotine from transdermal patches.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 4026

Your browser does not support the canvas element.


PDF Download: 1294

Your browser does not support the canvas element.

Submitted: 11 Feb 2018
Revision: 07 May 2018
Accepted: 20 May 2018
ePublished: 29 Aug 2018
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)