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Adv Pharm Bull. 2018;8(2): 353.
doi: 10.15171/apb.2018.041
PMID: 30023338
PMCID: PMC6046425
Scopus ID: 85048889509
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Erratum

Erratum to: Chirality of Modern Antidepressants: An Overview

Monica Budău, Gabriel Hancu*, Aura Rusu, Cârcu-Dobrin Melania, Daniela Lucia Muntean
*Corresponding Author: Email: gabriel.hancu@umftgm.ro

Abstract

The majority of modern antidepressants (selective serotonin reuptake inhibitors and selective serotonin and norepinephrine reuptake inhibitors) have one or two centers of asymmetry in their structure; resulting in the formation of enantiomers which may exhibit different pharmacodynamic and pharmacokinetic properties. Recent developments in drug stereochemistry has led to understanding the role of chirality in modern therapy correlated with increased knowledge regarding the molecular structure of specific drug targets and towards the possible advantages of using pure enantiomers instead of racemic mixtures. The current review deals with chiral antidepressant drugs; presenting examples of stereoselectivity in the pharmacological actions of certain antidepressants and their metabolites and emphasizing the differences between pharmacological actions of the racemates and pure enantiomers.
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Submitted: 13 Mar 2018
Revision: 11 May 2018
Accepted: 20 May 2018
ePublished: 21 May 2018
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