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Adv Pharm Bull. 2019;9(1): 48-55.
doi: 10.15171/apb.2019.006
PMID: 31011557
PMCID: PMC6468219
Scopus ID: 85065968715
  Abstract View: 804
  PDF Download: 437

Review Article

Testosterone May Hold Therapeutic Promise for the Treatment ofIschemic Stroke in Aging: A Closer Look at Laboratory Findings

Fereshteh Farajdokht 1 ORCID logo, Mehdi Farhoudi 1 ORCID logo, Alireza Majdi 1 ORCID logo, Masumeh Zamanlu 1 ORCID logo, Saeed Sadigh-Eteghad 1 ORCID logo, Shabnam Vahedi 1 ORCID logo, Javad Mahmoudi 1 * ORCID logo

1 Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Male sex is more prone to cerebrovascular disorders, yet the exact role of androgens in cerebralischemia remains unclear. Here we reviewed current understanding of testosterone (TES)neuroprotective activity against ischemic stroke and mechanisms underlying these effects inaging. TES may exert a neuroprotective effect in aging through pathways including inhibition ofoxidant molecules production, enhancing the enzymatic antioxidant capacity of the brain andmodulation of apoptotic cell death. Given this, a better understanding of the neuroprotectiveroles of TES may propose an effective therapeutic strategy to improve the quality of life anddecrease androgen-related cerebrovascular problems in the aging men.
Keywords: Male sex, Testosterone, Stroke, Oxidative stress, Apoptosis
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Submitted: 21 Apr 2018
Revision: 20 Dec 2018
Accepted: 22 Dec 2018
ePublished: 21 Feb 2019
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