Adv Pharm Bull. 2019;9(1):48-55.
doi: 10.15171/apb.2019.006
  Abstract View: 272
  PDF Download: 259

Review Article

Testosterone May Hold Therapeutic Promise for the Treatment ofIschemic Stroke in Aging: A Closer Look at Laboratory Findings

Fereshteh Farajdokht 1 ORCiD, Mehdi Farhoudi 1 ORCiD, Alireza Majdi 1 ORCiD, Masumeh Zamanlu 1 ORCiD, Saeed Sadigh-Eteghad 1 ORCiD, Shabnam Vahedi 1 ORCiD, Javad Mahmoudi 1 * ORCiD

1 Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran


Male sex is more prone to cerebrovascular disorders, yet the exact role of androgens in cerebralischemia remains unclear. Here we reviewed current understanding of testosterone (TES)neuroprotective activity against ischemic stroke and mechanisms underlying these effects inaging. TES may exert a neuroprotective effect in aging through pathways including inhibition ofoxidant molecules production, enhancing the enzymatic antioxidant capacity of the brain andmodulation of apoptotic cell death. Given this, a better understanding of the neuroprotectiveroles of TES may propose an effective therapeutic strategy to improve the quality of life anddecrease androgen-related cerebrovascular problems in the aging men.
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Submitted: 21 Apr 2018
Revised: 20 Dec 2018
Accepted: 22 Dec 2018
First published online: 21 Feb 2019
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