Adv Pharm Bull. 2019;9(1):102-109.
doi: 10.15171/apb.2019.013

Scopus id: 85062167991
  Abstract View: 117
  PDF Download: 131

Research Article

Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate

Mostafa Mabrouk 1 ORCiD, Sayed Hamed Kenawy 1 * ORCiD, Gehan El Tabie El-Bassyouni 1 ORCiD, Ahmed Abd El-Fattah Ibrahim Soliman 2 ORCiD, Esmat Mahmoud Aly Hamzawy 3 ORCiD

1 Refractories, Ceramics and Building Materials Department, National Research Centre (NRC), 33 El Behooth St. Dokki- Giza, Egypt.
2 Pharmacognosy Department, Pharmaceutical and Drug Industries Division, National Research Centre (NRC), 33 El Behooth St. Dokki, Giza, Egypt.
3 Glass Research Department, National Research Centre (NRC), 33 El Behooth St. Dokki- Giza, Egypt.

Abstract

Purpose: Different compositions of copper oxide (CuO)-doped calcium silicate clusters wereused to treat the cancer cells.Methods: The influence of CuO content on the morphology, drug delivering ability,physicochemical properties and cytotoxicity was investigated.Results: The microcrystalline structure revealed the decrement of the size from (20-36 nm) to(5-7 nm) depending on the copper content percentages. Drug delivering ability of doxycyclinehyclate (Dox) was down regulated from 58% to 28%in the presence of the CuO. The inclusionof CuO and Dox didn’t show any remarkable changes on the physicochemical properties of theCuO-doped calcium silicate nanoparticles.Conclusion: The CuO-doped calcium silicate sample (5 weight %) exhibited great cytotoxicityagainst the tested cell lines compared to the CuO-free sample. CuO-doped materials displayedsignificant anticancer effect; this sheds light on its implication in the treatment of cancer.
First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 117

Your browser does not support the canvas element.


PDF Downloaded: 131

Your browser does not support the canvas element.

Submitted: 13 May 2018
Revised: 15 Oct 2018
Accepted: 12 Nov 2018
First published online: 21 Feb 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)