Adv Pharm Bull. 2019;9(1): 102-109.
doi: 10.15171/apb.2019.013
PMID: 31011564
PMCID: PMC6468231
Scopus ID: 85062167991
  Abstract View: 765
  PDF Download: 610

Research Article

Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate

Mostafa Mabrouk 1 ORCID logo, Sayed Hamed Kenawy 1* ORCID logo, Gehan El Tabie El-Bassyouni 1 ORCID logo, Ahmed Abd El-Fattah Ibrahim Soliman 2 ORCID logo, Esmat Mahmoud Aly Hamzawy 3 ORCID logo

1 Refractories, Ceramics and Building Materials Department, National Research Centre (NRC), 33 El Behooth St. Dokki- Giza, Egypt.
2 Pharmacognosy Department, Pharmaceutical and Drug Industries Division, National Research Centre (NRC), 33 El Behooth St. Dokki, Giza, Egypt.
3 Glass Research Department, National Research Centre (NRC), 33 El Behooth St. Dokki- Giza, Egypt.


Purpose: Different compositions of copper oxide (CuO)-doped calcium silicate clusters wereused to treat the cancer cells.Methods: The influence of CuO content on the morphology, drug delivering ability,physicochemical properties and cytotoxicity was investigated.Results: The microcrystalline structure revealed the decrement of the size from (20-36 nm) to(5-7 nm) depending on the copper content percentages. Drug delivering ability of doxycyclinehyclate (Dox) was down regulated from 58% to 28%in the presence of the CuO. The inclusionof CuO and Dox didn’t show any remarkable changes on the physicochemical properties of theCuO-doped calcium silicate nanoparticles.Conclusion: The CuO-doped calcium silicate sample (5 weight %) exhibited great cytotoxicityagainst the tested cell lines compared to the CuO-free sample. CuO-doped materials displayedsignificant anticancer effect; this sheds light on its implication in the treatment of cancer.
Keywords: Copper oxide, Cytotoxicity, Doxycycline hyclate, Chemical precipitation
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Submitted: 13 May 2018
Revision: 15 Oct 2018
Accepted: 12 Nov 2018
ePublished: 21 Feb 2019
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