Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate

Mostafa Mabrouk; Sayed Hamed Kenawy; Gehan El Tabie El-Bassyouni; Ahmed Abd El-Fattah Ibrahim Soliman; Esmat Mahmoud Aly Hamzawy

doi:10.15171/apb.2019.013

Adv Pharm Bull. 2019;9(1): 102-109.
doi: 10.15171/apb.2019.013

PMID: 31011564
PMCID: PMC6468231
Scopus ID: 85062167991

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Research Article

Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate

Mostafa Mabrouk ¹ , Sayed Hamed Kenawy ¹^* , Gehan El Tabie El-Bassyouni ¹ , Ahmed Abd El-Fattah Ibrahim Soliman ² , Esmat Mahmoud Aly Hamzawy ³

¹ Refractories, Ceramics and Building Materials Department, National Research Centre (NRC), 33 El Behooth St. Dokki- Giza, Egypt.
² Pharmacognosy Department, Pharmaceutical and Drug Industries Division, National Research Centre (NRC), 33 El Behooth St. Dokki, Giza, Egypt.
³ Glass Research Department, National Research Centre (NRC), 33 El Behooth St. Dokki- Giza, Egypt.

*Corresponding Author: Email: ksayed6631@gmail.com

Abstract

Purpose: Different compositions of copper oxide (CuO)-doped calcium silicate clusters wereused to treat the cancer cells.Methods: The influence of CuO content on the morphology, drug delivering ability,physicochemical properties and cytotoxicity was investigated.Results: The microcrystalline structure revealed the decrement of the size from (20-36 nm) to(5-7 nm) depending on the copper content percentages. Drug delivering ability of doxycyclinehyclate (Dox) was down regulated from 58% to 28%in the presence of the CuO. The inclusionof CuO and Dox didn’t show any remarkable changes on the physicochemical properties of theCuO-doped calcium silicate nanoparticles.Conclusion: The CuO-doped calcium silicate sample (5 weight %) exhibited great cytotoxicityagainst the tested cell lines compared to the CuO-free sample. CuO-doped materials displayedsignificant anticancer effect; this sheds light on its implication in the treatment of cancer.

Keywords: Copper oxide, Cytotoxicity, Doxycycline hyclate, Chemical precipitation

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Article History

Submitted: 13 May 2018

Revision: 15 Oct 2018

Accepted: 12 Nov 2018

ePublished: 21 Feb 2019

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© 2019 The Author (s). This is an Open Access article distributed under the terms of the Creative Commons Attribution (CC BY), which permitsunrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is requiredfrom the authors or the publishers.