Adv Pharm Bull. 2019;9(2):231-240.
doi: 10.15171/apb.2019.026
  Abstract View: 59
  PDF Download: 74

Research Article

Novel Gliclazide Electrosprayed Nano-Solid Dispersions: Physicochemical Characterization and Dissolution Evaluation

Khosro Adibkia 1 ORCiD, Solmaz Ghajar 2,3 ORCiD, Karim Osouli-Bostanabad 4,3 ORCiD, Niloufar Balaei 2,3 ORCiD, Shahram Emami 5 ORCiD, Mohammad Barzegar-Jalali 6 * ORCiD

1 Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
5 Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
6 Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Purpose: In the current study, electrospraying was directed as a novel alternative approach to improve the physicochemical attributes of gliclazide (GLC), as a poorly water-soluble drug, by creating nanocrystalline/amorphous solid dispersions (ESSs).

Methods: ESSs were formulated using Eudragit® RS100 and polyethylene glycol (PEG) 6000 as polymeric carriers at various drug: polymer ratios (i.e. 1:5 and 1:10) with different total solution concentrations of 10, 15, and 20% w/v. Morphological, physicochemical, and in-vitro release characteristics of the developed formulations were assessed. Furthermore, GLC dissolution behaviors from ESSs were fitted to various models in order to realize the drug release mechanism.

Results: Field emission scanning electron microscopy analyses revealed that the size and morphology of the ESSs were affected by the drug: polymer ratios and solution concentrations. The polymer ratio augmentation led to increase in the particle size while the solution concentration enhancement yielded in a fiber establishment. Differential scanning calorimetry and powder X-ray diffraction investigations demonstrated that the ESSs were present in an amorphous state. Furthermore, the in vitro drug release studies depicted that the samples prepared employing PEG 6000 as carrier enhanced the dissolution rate and the model that appropriately fitted the release behavior of ESSs was Weibull model, where demonstrating a Fickian diffusion as the leading release mechanism. Fourier-transform infrared spectroscopy results showed a probability of complexation or hydrogen bonding, development between GLC and the polymers in the solid state.

Conclusion: Hence the electrospraying system avails the both nanosizing and amorphization advantages, therefore, it can be efficiently applied to formulating of ESSs of BCS Class II drugs.

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Submitted: 29 Jul 2018
Revised: 11 Jan 2019
Accepted: 14 Apr 2019
First published online: 01 Jun 2019
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