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Adv Pharm Bull. 2019;9(2): 289-293.
doi: 10.15171/apb.2019.033
PMID: 31380255
PMCID: PMC6664111
Scopus ID: 85068562431
  Abstract View: 362
  PDF Download: 294

Research Article

Evaluation the Effect of Amine Type on the Non-isothermally Derived Activation Energy for the Interaction of 3 Antidepressant Drugs with Lactose

Faranak Ghaderi 1 ORCID logo, Mahboob Nemati 2,3 ORCID logo, Mohammad Reza siahi-shadbad 3,4 ORCID logo, Hadi valizadeh 5 ORCID logo, Farnaz Monajjemzadeh 2,3,4 * ORCID logo

1 Department of Pharmaceutical and Food Control, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
2 Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Department of Pharmaceutical and Food Control, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
5 Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Purpose: Evaluation of drug-excipients compatibility is an important stage during preformulation studies. In the present research, differential scanning calorimetry (DSC) at different heating rates (2.5, 10, 15°C/min) was applied for the kinetic evaluation of fluvoxamine (FLM), sertraline (SER) and doxepin (DOX) binary mixtures with lactose.

Methods: Solid state kinetic parameters of the mixtures were calculated using two different thermal methods including ASTM E698 and Starink and the effect of amine type (pKa value) was investigated based on the calculated activation energies.

Results: Based on obtained results mean activation energy calculated for FLM, SER and DOX with lactose using ASTM E698 and Starink methods are equal to 335.23, 132.02 and 270.99 kJ/ mol respectively.

Conclusion: Results showed that the probability of drug-lactose interaction is higher in the SERlactose mixture in comparison with other two antidepressant drugs which is consistent with their pKa values.

Keywords: Interaction, DSC, Amine type, Lactose
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Submitted: 29 Aug 2018
Revision: 13 Mar 2019
Accepted: 14 Apr 2019
ePublished: 01 Jun 2019
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