Adv Pharm Bull. 2019;9(2):195-204.
doi: 10.15171/apb.2019.023
  Abstract View: 47
  PDF Download: 59

Review Article

Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting

Unnati Garg 1 ORCiD, Swati Chauhan 1 ORCiD, Upendra Nagaich 1 ORCiD, Neha Jain 1 * ORCiD

1 Amity Institute of Pharmacy, Amity University, Sector-125, Noida, Uttar Pradesh-201303.

Abstract

Nanoparticles (NPs) have been found to be potential targeted and controlled release drug delivery systems. Various drugs can be loaded in the NPs to achieve targeted delivery. Chitosan NPs being biodegradable, biocompatible, less toxic and easy to prepare, are an effective and potential tool for drug delivery. Chitosan is natural biopolymer which can be easily functionalized to obtain the desired targeted results and is also approved by GRAS (Generally Recognized as Safe by the United States Food and Drug Administration [US FDA]). Various methods for preparation of chitosan NPs include, ionic cross-linking, covalent cross-linking, reverse micellar method, precipitation and emulsion-droplet coalescence method. Chitosan NPs are found to have plethora of applications in drug delivery diagnosis and other biological applications. The key applications include ocular drug delivery, per-oral delivery, pulmonary drug delivery, nasal drug delivery, mucosal drug delivery, gene delivery, buccal drug delivery, vaccine delivery, vaginal drug delivery and cancer therapy. The present review describes the formation of chitosan, synthesis of chitosan NPs and their various applications in drug delivery.
First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 47

Your browser does not support the canvas element.


PDF Downloaded: 59

Your browser does not support the canvas element.

Submitted: 26 Sep 2018
Revised: 11 Jan 2019
Accepted: 13 Apr 2019
First published online: 01 Jun 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)