Adv Pharm Bull. 2019;9(2): 195-204.
doi: 10.15171/apb.2019.023
PMID: 31380245
PMCID: PMC6664124
Scopus ID: 85068566858
  Abstract View: 1187
  PDF Download: 968

Review Article

Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting

Unnati Garg 1 ORCID logo, Swati Chauhan 1 ORCID logo, Upendra Nagaich 1 ORCID logo, Neha Jain 1* ORCID logo

1 Amity Institute of Pharmacy, Amity University, Sector-125, Noida, Uttar Pradesh-201303.


Nanoparticles (NPs) have been found to be potential targeted and controlled release drug delivery systems. Various drugs can be loaded in the NPs to achieve targeted delivery. Chitosan NPs being biodegradable, biocompatible, less toxic and easy to prepare, are an effective and potential tool for drug delivery. Chitosan is natural biopolymer which can be easily functionalized to obtain the desired targeted results and is also approved by GRAS (Generally Recognized as Safe by the United States Food and Drug Administration [US FDA]). Various methods for preparation of chitosan NPs include, ionic cross-linking, covalent cross-linking, reverse micellar method, precipitation and emulsion-droplet coalescence method. Chitosan NPs are found to have plethora of applications in drug delivery diagnosis and other biological applications. The key applications include ocular drug delivery, per-oral delivery, pulmonary drug delivery, nasal drug delivery, mucosal drug delivery, gene delivery, buccal drug delivery, vaccine delivery, vaginal drug delivery and cancer therapy. The present review describes the formation of chitosan, synthesis of chitosan NPs and their various applications in drug delivery.
Keywords: Chitosan, Nanoparticles, Biodegradable, Applications, Drug Delivery
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Submitted: 26 Sep 2018
Revision: 11 Jan 2019
Accepted: 13 Apr 2019
ePublished: 01 Jun 2019
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