Adv Pharm Bull. 2019;9(2):241-248.
doi: 10.15171/apb.2019.027
  Abstract View: 154
  PDF Download: 150

Research Article

Multifunctional Cosmetic Containing Blueberry and Tinosorb M®- Loaded Microparticles Improves Sunscreen Performance

Daiana Schiavon 1, Daniela Novello Martini 1, Gabriela Brocco 1, Júlia Scherer Santos 2, Ana Paula Anzolin 3, Luciana Grazziotin Rossato-Grando 1,4, Hamid Omidian 5, Charise Dallazem Bertol 1,3 * ORCiD

1 Curso de Farmácia, Universidade de Passo Fundo, Passo Fundo, Brasil.
2 Curso de Farmácia, Centro Universitário União Dinâmica das Cataratas, Foz do Iguaçu, Paraná, Brasil.
3 Programa de Pós-Graduação em Envelhecimento Humano, Universidade de Passo Fundo, Passo Fundo, Brasil.
4 Programa de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo, Passo Fundo, Brasil.
5 Pharmaceutical Sciences, Nova Southeastern University, Fort Lauderdale, Florida, USA.


Purpose: We aimed to evaluate the effect of blueberry extract and microparticles (MPs) on sunscreen performance of multifunctional cosmetics. Octocrylene (OCT), benzophenone-3 (BENZ-3) and Tinosorb® M (MBBT) were employed as UV filters.

Methods: An in-silico modeling was used to determine the UV filters concentrations to obtain high values of sunscreen protection factor (SPF) and UVA protection factor (UVA-PF). MBBT and blueberryloaded microparticles (MPMB+B) and MBBT-loaded microparticles (MPMBBT) were prepared by spraydrying. OCT and BENZ-3 were added in the oil phase of cosmetics. Cosmetics A and B contained MPMB+B and MPMBBT, respectively, and cosmetic C was prepared without MP. Characterization, physicochemical stability and in vitro SPF was performed. UV filters distribution in human stratum corneum (SC) for each cosmetic was performed. Anti-oxidant activity of blueberry extract was evaluated.

Results: Sunscreen combination with the highest SPF was selected for formulations. Formulations A and B maintained their rheological behavior over time, unlike formulation C. In-vitro SPFs for formulations A, B and C were 51.0, 33.7 and 49.6, respectively. We also developed and validated a method for analysis of the UV filters by HPLC/ PDA suitable for the in-vivo assay. In Tape stripping test, MBBT showed SC distribution similar for all cosmetic formulations. OCT and BENZ-3 distribution to formulation A and C was also similar. Blueberry extract showed antioxidant capacity of 16.71 μg/mL equivalent to vitamin C.

Conclusion: Cosmetics containing MPs presented better physical stability. Blueberry increased the photoprotective capacity of the formulations and added extra benefits due to its anti-oxidant and anti-aging properties.

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Submitted: 22 Jan 2019
Revised: 22 Apr 2019
Accepted: 04 May 2019
First published online: 01 Jun 2019
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