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Adv Pharm Bull. 2020;10(3): 350-358.
doi: 10.34172/apb.2020.043
PMID: 32665893
PMCID: PMC7335993
Scopus ID: 85078628004
  Abstract View: 1439
  PDF Download: 1796
  Full Text View: 130

Review Article

Microbial Alpha-Amylase Production: Progress, Challenges and Perspectives

Babak Elyasi Far 1,2 ORCID logo, Yassin Ahmadi 3, Ahmad Yari Khosroshahi 1,4, Azita Dilmaghani 1,2* ORCID logo

1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.
*Corresponding Author: Azita Dilmaghani, Email: dilmaghani.a@tbzmed.ac.ir

Abstract

Alpha-amylase reputes for starch modification by breaking of 1-4 glycosidic bands and is widely applied in different industrial sectors. Microorganisms express unique alpha-amylases with thermostable and halotolerant characteristics dependent on the microorganism’s intrinsic features. Likewise, genetic engineering methods are applied to produce enzymes with higher stability in contrast to wild types. As there are widespread application of α-amylase in industry, optimization methods like RSM are used to improve the production of the enzyme ex vivo. This study aimed to review the latest researches on the production improvement and stability of α-amylase.
Keywords: Microbial, Alpha-amylase, RMS, Stability, Optimization
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Submitted: 29 Apr 2019
Revision: 23 Oct 2019
Accepted: 09 Nov 2019
ePublished: 11 May 2020
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