Adv Pharm Bull. 2020;10(1): 46-55.
doi: 10.15171/apb.2020.006
PMID: 32002361
PMCID: PMC6983987
Scopus ID: 85084150278
  Abstract View: 462
  PDF Download: 338

Research Article

Efficient Electrochemical Sensor Based on Gold Nanoclusters/Carbon Ionic Liquid Crystal for Sensitive Determination of Neurotransmitters and Anti-Parkinson Drugs

Nada Farouk Atta 1* ORCID logo, Ahmed Galal 1, Ekram Hamdy El-Ads 1, Aya Essam Galal 1

1 Chemistry Department, Faculty of Science, Cairo University, 12613 Giza, Egypt.


Purpose: Herein we introduce a simple and sensitive sensor for the electrochemical determination of neurotransmitters compounds and anti-Parkinson drugs.

Methods: The electrochemical sensor (Au/CILCE) based on gold nanoclusters modified carbon ionic liquid crystal (ILC) electrode was characterized using scanning electron microscopy and voltammetry measurements.

Results: The effect of ionic liquid type in the carbon paste composite for the electro-catalytic oxidation of L-dopa was evaluated. Highest current response was obtained in case of ILC compared to other studied kinds of ionic liquids. The effective combination of gold nanoclusters and ILC resulted in extra advantages including large surface area and high ionic conductivity of the nanocomposite. L-dopa is considered one of the most important prescribed medicines for treating Parkinson’s disease. Moreover, a binary therapy using L-dopa and carbidopa proved effective and promising as it avoids the short comings of L-dopa mono-therapy for Parkinson’s patients. The Au/CILCE can detect L-dopa in human serum in the linear concentration range of 0.1 μM to 90 μM with detection and quantification limits of 4.5 nM and 15.0 nM, respectively. Also, the Au/CILCE sensor can simultaneously and sensitively detect L-dopa in the presence of carbidopa with low detection limits.

Conclusion: The sensor is advantageous to be applicable for electrochemical sensing of other biologically electroactive species.

Keywords: Neurotransmitters, Anti-Parkinson drugs, Gold nanoclusters, Carbon ionic liquid crystal electrode, L-dopa, Carbidopa
First Name
Last Name
Email Address
Security code

Abstract View: 462

Your browser does not support the canvas element.

PDF Download: 338

Your browser does not support the canvas element.

Submitted: 17 May 2019
Revision: 27 Jul 2019
Accepted: 02 Sep 2019
ePublished: 11 Dec 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)