Adv Pharm Bull. 2020;10(2): 284-289.
doi: 10.34172/apb.2020.034
PMID: 32373498
PMCID: PMC7191243
Scopus ID: 85088692816
  Abstract View: 446
  PDF Download: 321

Research Article

Effects of Alpha Lipoic Acid Supplementation on Serum Levels of Oxidative Stress, Inflammatory Markers and Clinical Prognosis among Acute Ischemic Stroke Patients: A Randomized, Double Blind, TNS Trial

Sheyda Shaafi 1,2, Soraiya Ebrahimpour-Koujan 3, Mohammad Khalili 4,2* ORCID logo, Seyad Morteza Shamshirgaran 5, Mazyar Hashemilar 1,2 ORCID logo, Aliakbar Taheraghdam 1,2 ORCID logo, Seyed Kazem Shakouri 6 ORCID logo, Elyar Sadeghi Hokmabadi 1,2, Yaeghoub Ahmadi 1, Mehdi Farhoudi 1,2 ORCID logo, Nasim Rezaeimanesh 4, Daryoush Savadi Osgouei 1,2

1 Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
4 Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran.
5 Healthy Aging Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
6 Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
*Corresponding Author: Mohammad Khalili, Tel/Fax: +98 21 66348571, Email: nutrifoodkhalili@gmail.com


Purpose: Stroke is one of the most common conditions causing death. There have been few studies examining the effects of alpha lipoic acid (ALA) on stroke patients. In this regard, the present randomized controlled clinical trial was conducted to examine the effects of ALA supplementation on serum albumin, and inflammatory and oxidative stress markers in stroke patients.

Methods: The present paralleled randomized controlled clinical trial involved 42 stroke patients who were over 40 years and under enteral feeding. The participants were randomly assigned into two groups and finally 40 patients completed the study. Patients in alpha lipoic acid group (n=19) took 1200 mg ALA supplement daily along with their meal, and participants in control group (n=21) underwent the routine hospital diet for 3 weeks. Fasting blood samples were obtained and albumin, oxidative stress, and inflammatory indices were assessed at baseline, as well as at the end of the trial.

Results: After 3 weeks, treatment of patients with ALA led to a significant decrease in tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) levels (P=0.01) compared to baseline. But serum levels of albumin, total antioxidant capacity (TAC), malondialdehyde (MDA), highsensitivity C-reactive protein (hs-CRP), IL-6 and TNF-α did not change significantly vs. control group (P>0.05).

Conclusion: ALA did not significantly change the serum levels of albumin and inflammatory as well as antioxidant capacity indices in stroke patients compared with the control group. More clinical trials with large sample sizes and long duration are needed to clarify the effects of ALA on these patients.

Keywords: Alpha lipoic acid, Inflammation, Oxidative stress, Stroke
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Submitted: 22 May 2019
Revision: 12 Aug 2019
Accepted: 30 Sep 2019
ePublished: 18 Feb 2020
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