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Adv Pharm Bull. 2020;10(3): 418-422.
doi: 10.34172/apb.2020.050
  Abstract View: 67
  PDF Download: 57

Research Article

Evaluation of Microcrystalline Cellulose Derived from Saccharum officinarum L. (Sugarcane) Leaves as a Disintegrant in Tablet Formulations

Julie Ann S. Ng * ORCID logo

1 College of Pharmacy, Riverside College, Inc., BS Aquino Dr, Bacolod, 6100 Negros Occidental, the Philippines.

Abstract

Purpose: Complete recycling of the crop residues of sugarcane in the Philippines remains to beachieved. This study purposed to derive microcrystalline cellulose (MCC) from sugarcane leavesand test its disintegrating properties in tablet formulation.Methods: Saccharum officinarum L. (sugarcane) leaves were used to prepare MCC powder.According to the conventional method, the preparation of cellulose powder requires heatingthe raw material with acid and alkali followed by washing, bleaching, and sieving. Hydrolysisof the bleached product was carried out using hydrochloric acid to obtain MCC powder, andthe physicochemical properties of the produced MCC powder were studied including itsorganoleptic properties, pH value, %loss on drying, %water soluble substances and Fouriertransforminfrared (FTIR) spectrum.Results: The resulting powder was evaluated for its disintegrating property in the preparationof blank tablets, which were compared to tablets prepared using commercially available MCC.MCC powder derived from sugarcane leaves had properties at par with commercially availableMCC and was in conformance with National Formulary (NF) specifications.Conclusion: Disintegrating properties were also significantly better than the commerciallyavailable MCC.
Keywords: Disintegrant, FTIR, Microcrystalline cellulose National formulary, Organoleptic, pH, Sugarcane
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Submitted: 19 Jun 2019
Revision: 28 Jan 2020
Accepted: 03 Feb 2020
ePublished: 11 May 2020
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