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Adv Pharm Bull. 2020;10(1): 106-113.
doi: 10.15171/apb.2020.013
PMID: 32002368
PMCID: PMC6983997
Scopus ID: 85084146039
  Abstract View: 418
  PDF Download: 369

Research Article

Association of Omentin-1 with Oxidative Stress and Clinical Significances in Patients with Breast Cancer

Nahideh Tahmasebpour 1, Mohammad Ali Hosseinpour Feizi 2, Nasrin Ziamajidi 1, Naser Pouladi 3, Vahid Montazeri 4, Maryam Farhadian 5 ORCID logo, Roghayeh Abbasalipourkabir 1* ORCID logo

1 Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
2 Department of Animal Biology, Faculty of Natural Science, Tabriz University, Tabriz, Iran.
3 Department of Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.
4 Department of Thoracic Surgery, Faculty of Medicine, Surgery Ward, Nour-Nejat Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
5 Department of Biostatistics, School of Public Health and Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.

Abstract

Purpose: Breast cancer (BC) is globally the main reason of cancer-related deaths in women. Omentin-1, an anti-inflammatory and antioxidant adipokine, plays different roles in tumorigenesis and anti-oncogenic pathways. In present study, we investigated the association of omentin-1 with oxidative stress and clinical significances in healthy controls and BC patients to assess the prognostic and diagnostic value of omentin-1 in this cancer.

Methods: This case-control study included 88 BC patients and 86 healthy controls. The serum levels of omentin-1 were assessed by enzyme-linked immunosorbent assays methods. Also, total antioxidant capacity (TAC), total oxidant status (TOS) and malondialdehyde (MDA) serum levels were measured by spectrophotometer. quantitative real-time polymerase chain reaction (qRT-PCR) was applied to the measurement of gene expression of omentin-1.

Results: the serum levels of omentin-1 were significantly lower in the BC patients compared to the healthy controls (P<0.001). Moreover, gene expression of omentin-1was significantly downregulated in the BC tissues compared to the adjacent normal tissues (P<0.001). Gene expression of omentin-1and its serum levels were significantly higher in grade I compared with grade II and III (P=0.001, P<0.001, respectively). Additionally, the serum levels of omentin-1 in the p53-positive BC patients were significantly higher than the p53-negative BC patients (P=0.001). There was an inverse correlation between the serum levels of MDA and TOS with the serum levels of omentin-1 (r=-0.436, r=-461, respectively).

Conclusion: We conclude that omentin-1 may have a good prognostic and diagnostic roles in the BC patients and decreases oxidative stress in these patients.

Keywords: Breast neoplasms, Omentin-1, Clinical, Antioxidant, Prognosis, Gene expression
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Submitted: 15 Jul 2019
Revision: 05 Sep 2019
Accepted: 18 Sep 2019
ePublished: 11 Dec 2019
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