Adv Pharm Bull. 2020;10(3): 477-481.
doi: 10.34172/apb.2020.059
PMID: 32665909
PMCID: PMC7335984
Scopus ID: 85088613589
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Short Communication

Non-Classical Effects of the cAMP Accumulation Activators In Vivo

Artur Martynov 1* ORCID logo, Tatyana Bomko 1, Tatyana Nosalskaya 1, Boris Farber 2, Ostap Brek 3

1 Mechnikov Institute of Microbiology and Immunology, National Academy of Medical Sciences of Ukraine, Kharkov, Ukraine.
2 Noigel LLC, R & D department, New-York, USA.
3 Kharkiv National Medical University, 195-Moskovsky prospect, Kharkov, Ukraine.
*Corresponding Author: Artur Martynov, Email: imiamn@gmail.com


Purpose: Wound-healing dipyridamole- and papaverine-based aerosols (D1/D2) as activators of the accumulation of cyclic adenosine monophosphate are promising drugs that can accelerate wound healing in wound processes of various origins.

Methods: 128 rats were used in the study, including 38 in a pharmacological experiment on a model of stencil wounds and 90 in an experiment that studied the effect of spray on the number of CD34 cells in the blood of rats with chemically induced immunodeficiency. Immunodeficiency was caused by the fivefold administration of cyclophosphamide and prednisone. The expression level of CD34 was determined using flow cytofluorimeter.

Results: Dipyridamole- and papaverine-based aerosols of two compositions (with and without ascorbic acid) have pronounced reparative properties, significantly accelerating epithelialization and healing of stencil wounds in rats. In terms of this type of action, they are somewhat superior to dexpanthenol. Dipyridamole- and papaverine-based aerosols have the ability to produce beneficial effect on the entire body’s immune system by stimulating the division of pluripotent CD34 cells. The combined effect of papaverine and dipyridamole on tissues leads to selective stimulation of the division of pluripotent cells in the wound, and contributes to a six-fold acceleration of restoration of the animal’s immune system after induced immunodeficiency.

Conclusion: Topical application of D1/D2 aerosol samples on the skin of rats contributed to a statistically significant acceleration of regeneration processes. In terms of the appearance of granulations and epithelialization of wounds, D1/D2 aerosols were superior to dexpanthenol ointment.

Keywords: Dipyridamole, Papaverine, Aerosols, CD34 + cells, Regeneration, Wound healing
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Submitted: 28 Aug 2019
Revision: 10 Dec 2019
Accepted: 27 Jan 2020
ePublished: 11 May 2020
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