Adv Pharm Bull. 2020;10(3): 477-481.
doi: 10.34172/apb.2020.059
  Abstract View: 51
  PDF Download: 38

Short Communication

Non-Classical Effects of the cAMP Accumulation Activators in Vivo

Artur Martynov 1 * ORCID logo, Tatyana Bomko 1, Tatyana Nosalskaya 1, Boris Farber 2, Ostap Brek 3

1 Mechnikov Institute of Microbiology and Immunology, National Academy of Medical Sciences of Ukraine, Kharkov, Ukraine.
2 Noigel LLC, R & D department, New-York, USA.
3 Kharkiv National Medical University, 195-Moskovsky prospect, Kharkov, Ukraine.


Purpose: Wound-healing dipyridamole- and papaverine-based aerosols (D1/D2) as activators ofthe accumulation of cyclic adenosine monophosphate are promising drugs that can acceleratewound healing in wound processes of various origins.Methods: 128 rats were used in the study, including 38 in a pharmacological experiment on amodel of stencil wounds and 90 in an experiment that studied the effect of spray on the numberof CD34 cells in the blood of rats with chemically induced immunodeficiency. Immunodeficiencywas caused by the fivefold administration of cyclophosphamide and prednisone. The expressionlevel of CD34 was determined using flow cytofluorimeter.Results: Dipyridamole- and papaverine-based aerosols of two compositions (with and withoutascorbic acid) have pronounced reparative properties, significantly accelerating epithelializationand healing of stencil wounds in rats. In terms of this type of action, they are somewhat superior todexpanthenol. Dipyridamole- and papaverine-based aerosols have the ability to produce beneficialeffect on the entire body’s immune system by stimulating the division of pluripotent CD34 cells.The combined effect of papaverine and dipyridamole on tissues leads to selective stimulationof the division of pluripotent cells in the wound, and contributes to a six-fold acceleration ofrestoration of the animal’s immune system after induced immunodeficiency.Conclusion: Topical application of D1/D2 aerosol samples on the skin of rats contributed toa statistically significant acceleration of regeneration processes. In terms of the appearance ofgranulations and epithelialization of wounds, D1/D2 aerosols were superior to dexpanthenolointment.
Keywords: Dipyridamole, Papaverine, Aerosols, CD34 + cells, Regeneration, Wound healing
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Submitted: 28 Aug 2019
Revision: 10 Dec 2019
Accepted: 27 Jan 2020
ePublished: 11 May 2020
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