Adv Pharm Bull. 2021;11(2): 224-232.
doi: 10.34172/apb.2021.026
  Abstract View: 563
  PDF Download: 281

Review Article

Effects of Medicinal Plants and Flavonoids on Parkinson’s Disease: A Review on Basic and Clinical Evidences

Mohammad Reza Khazdair 1 ORCID logo, Majid Kianmehr 2, Akbar Anaeigoudari 3* ORCID logo

1 Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
2 Esfarayen Faculty of Medical Sciences, Esfarayen, Iran.
3 Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.
*Corresponding Author: Akbar Anaeigoudari, Tel:+98-(34)(43317902), Email: Anaeia@jmu.ac.ir


Parkinson’s disease (PD) is a neurodegenerative disorder which is characterized by typical symptoms including gradual progressive muscle rigidity, tremor and loss of motor skills. Although there is no definitive cure for PD, the extract of some medicinal plants and their ingredients have been suggested to relieve its symptoms and to prevent disability in patients. This review is focused on therapeutic effects of some medicinal plants and their ingredients on PD. The findings presented in this review were collected from experimental and clinical studies in databases including PubMed, Web of Science and Google Scholar until the end of May 2019. The keywords “neurotoxicity “ or “Parkinson’s disease” or “neuroprotective” and “Medicinal plants” and “Flavonoids” were searched. Based on the results of animal and clinical studies, the extract of medicinal plants and their components which are discussed in this review have neuro-protective effects against PD. These protective properties mainly are mediated through inhibition of dopamine metabolizing enzymes, reduction oxidant markers, increase of antioxidant agents and suppression of neuro-inflammation.

Keywords: Parkinson's disease, Neurotoxicity, Medicinal plants, Flavonoids
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Submitted: 07 Nov 2019
Revision: 27 Apr 2020
Accepted: 30 Jun 2020
ePublished: 01 Jul 2020
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