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Adv Pharm Bull. 2021;11(1): 111-119.
doi: 10.34172/apb.2021.012
  Abstract View: 86
  PDF Download: 26

Research Article

Sodium Dodecyl Sulfate Modified Carbon Nano Tube Paste Electrode for Sensitive Cyclic Voltammetry Determination of Isatin

Amrutha Balliamada Monnappa 1,2 ORCID logo, Jamballi Gangadharappa Manjunatha 1* ORCID logo, Aarti Sripathi Bhatt 2*, Kodi Malini 3

1 Department of Chemistry, FMKMC College, Madikeri, Constituent College of Mangalore University, Karnataka, India.
2 Department of Chemistry, N.M.A.M. Institute of Technology, (Visvesvaraya Technological University, Belgavi) Nitte, 574110, Udupi District, Karnataka, India.
3 Department of Chemistry, St Philomina College, Puttur, Dakshina Kannada, Karnataka, India.
*Corresponding Authors: Jamballi Gangadarappa Manjunatha and Aarti Sripathi Bhatt, Tel.: +91- 08272228334, Email: manju1853@gmail. com; artis@nitte edu.in

Abstract

Purpose: Isatin (IS) is a synthetically significant heterocyclic moiety with an influential pharmacodynamic indole nucleus and hence the electrocatalytic property of has been investigated.

Methods: The electrochemical analysis was demonstrated by cyclic voltammetry (CV) in the potential window of 0.2 V to 1.4 V using sodium dodecyl sulfate (SDS) modified carbon nano tube paste electrode (SDSMCNTPE) over a pH range of 6 to 8.5 in 0.2 M phosphate buffer solution (PBS). Surface morphology was studied by using Field emission-scanning electron microscopy (FESEM).

Results: The CV study discloses that under ideal condition oxidation of IS arises at a potential of 0.970 V accompanied with an exceptional stability, selectivity and sensitivity for the resultant SDSMCNTPE contrasting to bare carbon nano tube paste electrode (BCNTPE). Individual parameters like electrode surface area, effect of surfactant, detection limit, simultaneous detection of IS and resorcinol (RC) were studied at a scan rate of 0.1 V/s. Scan rate study uncovers the process is diffusion controlled. The oxidation peak current amplified linearly with the surge in concentration of IS under ideal condition. Detection limit (LOD) and limit of quantification (LOQ) in the solution of optimum pH (7.5) at a scan rate of 0.100V/s is 2.4×10-7 M and 8.2 × 10-7 M respectively.

Conclusion: The proposed electrode portrays excellent repeatability, reproducibility and reliability to resistant electrode fouling.

Keywords: Cyclic Voltammetry, Carbon nanotube paste electrode, SDS, Isatin, Resorcinol
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Submitted: 27 Nov 2019
Revision: 13 Apr 2020
Accepted: 15 Apr 2020
ePublished: 07 Nov 2020
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