Adv Pharm Bull. 2021;11(1): 111-119.
doi: 10.34172/apb.2021.012
PMID: 33747858
PMCID: PMC7961235
Scopus ID: 85096953712
  Abstract View: 1435
  PDF Download: 688
  Full Text View: 303

Research Article

Sodium Dodecyl Sulfate Modified Carbon Nano Tube Paste Electrode for Sensitive Cyclic Voltammetry Determination of Isatin

Amrutha Balliamada Monnappa 1,2 ORCID logo, Jamballi Gangadharappa Manjunatha 1* ORCID logo, Aarti Sripathi Bhatt 2*, Kodi Malini 3

1 Department of Chemistry, FMKMC College, Madikeri, Constituent College of Mangalore University, Karnataka, India.
2 Department of Chemistry, N.M.A.M. Institute of Technology, (Visvesvaraya Technological University, Belgavi) Nitte, 574110, Udupi District, Karnataka, India.
3 Department of Chemistry, St Philomina College, Puttur, Dakshina Kannada, Karnataka, India.
*Corresponding Authors: *Corresponding Authors: Jamballi Gangadarappa Manjunatha and Aarti Sripathi Bhatt, Tel.: +91- 08272228334, Email: manju1853@gmail. com; , Email: artis@nitte edu.in; Email: MNAJUJG@GMAIL.COM


Purpose: Isatin (IS) is a synthetically significant heterocyclic moiety with an influential pharmacodynamic indole nucleus and hence the electrocatalytic property of has been investigated.

Methods: The electrochemical analysis was demonstrated by cyclic voltammetry (CV) in the potential window of 0.2 V to 1.4 V using sodium dodecyl sulfate (SDS) modified carbon nano tube paste electrode (SDSMCNTPE) over a pH range of 6 to 8.5 in 0.2 M phosphate buffer solution (PBS). Surface morphology was studied by using Field emission-scanning electron microscopy (FESEM).

Results: The CV study discloses that under ideal condition oxidation of IS arises at a potential of 0.970 V accompanied with an exceptional stability, selectivity and sensitivity for the resultant SDSMCNTPE contrasting to bare carbon nano tube paste electrode (BCNTPE). Individual parameters like electrode surface area, effect of surfactant, detection limit, simultaneous detection of IS and resorcinol (RC) were studied at a scan rate of 0.1 V/s. Scan rate study uncovers the process is diffusion controlled. The oxidation peak current amplified linearly with the surge in concentration of IS under ideal condition. Detection limit (LOD) and limit of quantification (LOQ) in the solution of optimum pH (7.5) at a scan rate of 0.100V/s is 2.4×10-7 M and 8.2 × 10-7 M respectively.

Conclusion: The proposed electrode portrays excellent repeatability, reproducibility and reliability to resistant electrode fouling.

First Name
Last Name
Email Address
Security code

Abstract View: 1389

Your browser does not support the canvas element.

PDF Download: 688

Your browser does not support the canvas element.

Full Text View: 303

Your browser does not support the canvas element.

Submitted: 27 Nov 2019
Revision: 13 Apr 2020
Accepted: 15 Apr 2020
ePublished: 07 Nov 2020
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)