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Adv Pharm Bull. 2020;10(3): 338-349.
doi: 10.34172/apb.2020.042
PMID: 32665892
PMCID: PMC7335982
Scopus ID: 85088618513
  Abstract View: 1863
  PDF Download: 1069
  Full Text View: 405

Review Article

Recent Advances in Targeting of Breast Cancer Stem Cells Based on Biological Concepts and Drug Delivery System Modification

Zeynab Aaliyari-Serej 1,2,3 ORCID logo, Ayyub Ebrahimi 4 ORCID logo, Balal Barazvan 5, Abbas Ebrahimi-Kalan 6 ORCID logo, Khalil Hajiasgharzadeh 2 ORCID logo, Tohid Kazemi 7, Behzad Baradaran 2,7* ORCID logo

1 Department of Applied Cell Sciences, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Halic Uuniversity, Istanbul, Turkey.
5 Department of Basic Sciences, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
6 Department of Neurosciences and Cognition, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
7 Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. .
*Corresponding Author: *Corresponding Author: Behzad Baradaran, Tel: +98 41 33371440/+98 41 33364665, Email: , Email: baradaranb@tbzmed.ac.ir

Abstract

Breast cancer with various biological diversity known as the common reason of death in the world and despite progress in novel therapeutic approaches, it faced with failure and recurrence in general. Recent clinical and preclinical statistics support cancer stem cells (CSCs) hypothesis and its similarities with normal stem cells. Evaluation of related paper conclude in significance finding in the further characterization of CSCs biology such as surface biomarkers, microenvironment regulatory molecules, cell signaling pathways, cell to cell transition and drug efflux pumps to overcome multidrug resistance and effective therapy. Emerging novel data indicate biological concepts in the base of unsuccessful treatment. A powerful understanding of the cell signaling pathways in cancer and CSCs topics can be led us to define and control treatment problems in cancer. More recently nano medicine based on drug delivery system modification and new implications on combinatorial therapy have been used to treat breast cancer effectively. The aim of this review is focus on CSCs as a potential target of cancer therapy, to overcome the limitation and problems of current therapeutic strategies in cancer.
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Submitted: 09 Nov 2019
Revision: 03 Dec 2019
Accepted: 05 Dec 2019
ePublished: 11 May 2020
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