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Adv Pharm Bull. 2020;10(3): 338-349.
doi: 10.34172/apb.2020.042
  Abstract View: 91
  PDF Download: 76

Review Article

Recent Advances in Targeting of Breast Cancer Stem Cells Based on Biological Concepts and Drug Delivery System Modification

Zeynab Aaliyari-Serej 1,2,3 ORCID logo, Ayyub Ebrahimi 4 ORCID logo, Balal Barazvan 5, Abbas Ebrahimi-Kalan 6 ORCID logo, Khalil Hajiasgharzadeh 2 ORCID logo, Tohid Kazemi 7, Behzad Baradaran 2,7 * ORCID logo

1 Department of Applied Cell Sciences, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Halic Uuniversity, Istanbul, Turkey.
5 Department of Basic Sciences, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
6 Department of Neurosciences and Cognition, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
7 Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. .

Abstract

Breast cancer with various biological diversity known as the common reason of death inthe world and despite progress in novel therapeutic approaches, it faced with failure andrecurrence in general. Recent clinical and preclinical statistics support cancer stem cells (CSCs)hypothesis and its similarities with normal stem cells. Evaluation of related paper conclude insignificance finding in the further characterization of CSCs biology such as surface biomarkers,microenvironment regulatory molecules, cell signaling pathways, cell to cell transition anddrug efflux pumps to overcome multidrug resistance and effective therapy. Emerging novel dataindicate biological concepts in the base of unsuccessful treatment. A powerful understandingof the cell signaling pathways in cancer and CSCs topics can be led us to define and controltreatment problems in cancer. More recently nano medicine based on drug delivery systemmodification and new implications on combinatorial therapy have been used to treat breastcancer effectively. The aim of this review is focus on CSCs as a potential target of cancer therapy,to overcome the limitation and problems of current therapeutic strategies in cancer.
Keywords: Breast cancer, Cancer stem cells, Cell signaling, Multi-drug resistance, Nanomedicine
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Submitted: 09 Nov 2019
Revision: 03 Dec 2019
Accepted: 05 Dec 2019
ePublished: 11 May 2020
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