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Adv Pharm Bull. 2022;12(4): 818-827.
doi: 10.34172/apb.2022.087

Scopus ID: 85140272667
  Abstract View: 553
  PDF Download: 283
  Full Text View: 146

Research Article

Preparation and Antiproliferative Activity Evaluation of Juglone-Loaded BSA Nanoparticles

Ali Jahanban-Esfahlan 1 ORCID logo, Soodabeh Davaran 2,3, Siavoush Dastmalchi 1,2,4* ORCID logo

1 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Faculty of Pharmacy, Near East University, POBOX: 99138, Nicosia, North Cyprus, Mersin 10, Turkey.
*Corresponding Author: Faculty of Pharmacy, Near East University, POBOX: 99138, Nicosia, North Cyprus, Mersin 10, Turkey. Email dastmalchi.s@tbzmed.ac.ir
*Corresponding Author: Corresponding Author: Siavoush Dastmalchi, Tel: + 98 41 33364038, Email: , Email: dastmalchi.s@tbzmed.ac.ir

Abstract

Purpose: Today, the discovery of novel and effective chemotherapeutic compounds is the mainchallenge in cancer therapy. In recent years, the anti-tumoral activity of natural naphthoquinonejuglone (JUG), present in different parts of walnut trees, has received considerable interest. Thepurpose of the current study was to prepare and evaluate the in vitro antiproliferative activity ofJUG-loaded bovine serum albumin nanoparticles (JUG-BSA NPs).Methods: BSA NPs and JUG-BSA NPs were prepared using the desolvation technique. The NPswere characterized for their particle size (PS), zeta potential (ZP), drug loading (DL) capacityand encapsulation efficiency (EE). The anti-proliferative activity of JUG-BSA NPs was evaluatedon A431 and HT29 cancer cell lines using cellular uptake and MTT assays.Results: The PS and ZP values of JUG-BSA NPs were 85 ± 6.55 nm and −29.6 mV, respectively.The DL capacity and EE were 3.7% to 5% and 50.4% to 94.6%, respectively. The cytotoxicityof JUG-BSA NPs was significantly less on both cultured A431 and HT29 cells at the studiedconcentrations when compared to free JUG. However, the effect was not very substantial,particularly at high levels.Conclusion: In conclusion, BSA NPs can be used as a suitable and safe carrier for the deliveryof JUG, a cytotoxic hydrophobic natural compound.
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Submitted: 24 Feb 2020
Revision: 11 Dec 2021
Accepted: 31 Dec 2021
ePublished: 03 Jan 2022
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