Adv Pharm Bull. 2021;11(3): 497-504.
doi: 10.34172/apb.2021.057
  Abstract View: 336
  PDF Download: 24

Research Article

Antibacterial Activities of Phytofabricated ZnO and CuO NPs by Mentha pulegium Leaf/flower Mixture Extract against Antibiotic Resistant Bacteria

Mehran Alavi 1,2* ORCID logo, Saeed Dehestaniathar 1* ORCID logo, Shadieh Mohammadi 1, Afshin Maleki 1, Naser Karimi 2

1 Environmental Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
2 Nanobiotechnology Laboratory, Biology Department, Faculty of Science, Razi University, Kermanshah, Iran.


Purpose: In this study, leaf/flower aqueous extract of medicinal plant species Mentha pulegium was used to synthesize ZnO and CuO nanoparticles (NPs) as a cost-effective, one-step, and eco-friendly method. Methods: Physicochemical properties of both metal oxide NPs (MONPs) were determined by UV-Vis spectroscopy, X-Ray Diffraction (XRD), Fourier-Transform Infra-Red (FTIR) spectroscopy, Scanning Electron Microscope (SEM) and Energy Dispersive X-ray (EDX) techniques.
Results: Phytofabricated ZnONPs and CuNPs illustrated 65.02±7.55 and 26.92±4.7 nm with antibacterial activities against antibiotic-resistant Escherichia coli and Staphylococcus aureus. Higher antibacterial activities were observed for CuONPs compared with ZnONPs.
Conclusion: Large surface area and more reactivity resulted from smaller size as well as higher production of reactive oxygen species (ROS) were considered to antibacterial efficiency of CuONPs against antibiotic-resistant E. coli and S. aureus.
Keywords: Phytosynthesis, Metal oxide NPs, Mentha pulegium, Antibiotic resistance, Antibacterial activities
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Submitted: 04 Apr 2020
Revision: 02 Aug 2020
Accepted: 05 Aug 2020
ePublished: 05 Aug 2020
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