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Adv Pharm Bull. 2021;11(4): 765-771.
doi: 10.34172/apb.2021.086
  Abstract View: 347
  PDF Download: 35

Short Communication

Physical Characterization and Biodistribution of Cisplatin Loaded in Surfactant Modified-Hybrid Nanoparticles Using Polyethylene Oxide-b-Polymethacrylic Acid

Andang Miatmoko* ORCID logo

1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenoes Building, Campus C Mulyorejo, Surabaya, 60115, Indonesia.
*Corresponding Author: Andang Miatmoko, Tel/Fax: +62 31 5933-150/+62 31 5935-249, E-mail: andang-m@ff.unair.ac.id

Abstract

Purpose: Conjugating cisplatin into hybrid nanoparticles is intended to enhance tumor accumulation in cancer therapy due to drug interaction with polymer and prevent premature drug release because of the presence of a lipid layer.

Methods: Hybrid nanoparticles composed of polyethylene oxide-b-polymethacrylic acid, egg phosphatidylcholine, and surfactant, i.e. sodium cholate/sodium deoxycholate/Tween 80, were prepared by the injection method. Cisplatin was subsequently loaded by incubating the polymer-drug mixtures at the molar ratio of carboxylate ions of 2:1.

Results: The results showed that the addition of surfactants produced particle sizes between 33 and 52 nm. The addition of cisplatin increased the ζ-potential to slightly positive charges with encapsulation efficiencies of 5%-18%. An in vivo biodistribution study of mice identified a cisplatin plasma concentration of sodium cholate-modified hybrid nanoparticles 10 times higher than cisplatin solution, thus producing high tumor accumulation.

Conclusion: Conjugating cisplatin into sodium cholate-modified hybrid nanoparticles improves its accumulation in tumors.


Keywords: Cisplatin, Cancer, Egg phosphatifylcholine, Hybrid nanoparticles, Polyethylene oxide-b-polymethacrylic acid, Surfactants

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Submitted: 25 May 2020
Revision: 05 Aug 2020
Accepted: 17 Oct 2020
ePublished: 20 Oct 2020
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