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Adv Pharm Bull. 2022;12(4): 801-817.
doi: 10.34172/apb.2022.082
PMID: 36415630
PMCID: PMC9675925
Scopus ID: 85133953385
  Abstract View: 759
  PDF Download: 282
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Research Article

Artificial Neural Network Modeling of Nanostructured Lipid CarriersContaining 5-O-Caffeoylquinic Acid-Rich Cratoxylum formosum LeafExtract for Skin Application

Abhiruj Navabhatra 1 ORCID logo, Adelheid Brantner 2 ORCID logo, Bancha Yingngam 3* ORCID logo

1 Department of Pharmacology, College of Pharmacy, Rangsit University, Pathum Thani, 12000, Thailand.
2 Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Universitaetsplatz 4/1, A-8010, Graz, Austria.
3 Department of Pharmaceutical Chemistry and Technology, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand.
*Corresponding Author: Corresponding Author: Bancha Yingngam, Tel: +66 (0) 45 353630, Email: , Email: bancha.y@ubu.ac.th

Abstract

Purpose: To investigate the in vitro anti-skin-aging properties of Cratoxylum formosumextract and encapsulate this plant extract in nanostructured lipid carriers (CFE-NLCs) fordermal application.Methods: The biological properties of the plant extract, including enhanced procollagen typeI synthesis and anti-matrix metalloproteinase activity, were evaluated to assess its cosmeticbenefits. An artificial neural network (ANN) coupled with K-fold cross-validation was appliedto investigate the effects of the formulants and optimize the CFE-NLCs. The physicochemicalproperties, percutaneous absorption, and irritation potential of the CFE-NLCs were analyzed.Results: Liquid chromatography-mass spectrometry analysis revealed that CFE contained5-O-caffeoylquinic acid as the vital constituent. Appropriate skin-care properties were alsodemonstrated with respect to enhanced type I procollagen synthesis and the inhibition of MMP-1, MMP-3, and MMP-9 in primary human dermal fibroblasts. The optimal CFE-NLCs exhibitedbetter skin absorption and biocompatibility and lower irritation potential than the free botanicalextract solution.Conclusion: The findings obtained highlight CFE-NLCs as promising skin-care ingredients.
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Submitted: 18 Jan 2021
Revision: 21 May 2021
Accepted: 28 Sep 2021
ePublished: 06 Oct 2021
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