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Adv Pharm Bull. 2022;12(4): 747-756.
doi: 10.34172/apb.2022.076
PMID: 36415634
PMCID: PMC9675916
Scopus ID: 85140274850
  Abstract View: 745
  PDF Download: 403
  Full Text View: 147

Review Article

Role of Fungal Infections in Carcinogenesis and Cancer Development:A Literature Review

Kamran Hosseini 1,2 ORCID logo, Hossein Ahangari 3, Florence Chapeland-leclerc 4, Gwenael Ruprich-Robert 4, Vahideh Tarhriz 5* ORCID logo, Azita Dilmaghani 6,7* ORCID logo

1 Department of Molecular Medicine, Faculty of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
3 Department of Food Science and Technology, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Université de Paris, Faculté des Sciences, Laboratoire Interdiciplinaire des Energies de Demain (LIED), UMR 8236 CNRS, F-75013, Paris, France.
5 Molecular Medicine Research Center, Bio-Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
6 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
7 Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
*Corresponding Authors: Corresponding Author: Vahideh Tarhriz , Email: , Email: t.tarhriz@yahoo.com; Corresponding Author: Azita Dilmaghani, Email: , Email: dilmaghani.a@gmail.com

Abstract

Cancer is a serious debilitating disease and one of the most common causes of death. In recentdecades the high risk of various cancers enforced scientists to discover novel prevention andtreatment methods to diminish the mortality of this terrifying disease. Accordingly, its preventioncan be possible in near future. Based on epidemiological evidence, there is a clear link betweenpathogenic fungal infections and cancer development. This association is often seen in peoplewith weakened immune systems such as the elderly and people with acquired immunodeficiency(AIDS). Carcinoma in these people is first seen chronically and then acutely. Although thedifferent genetic and environmental risk factors are involved in carcinogenesis, one of the mostimportant risk factors is fungal species and infections associating with cancers etiology. Now itis known that microbial infection is responsible for initiating 2.2 million new cancer cases. Inthis way, many recent studies have focused on investigating the role and mechanism of fungalinfections in diverse cancers occurrence. This review provides a comprehensive frameworkof the latest clinical findings and the association of fungal infections with versatile cancersincluding esophageal, gastric, colorectal, lung, cervical, skin, and ovarian cancer.
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Submitted: 07 Apr 2021
Revision: 02 Aug 2021
Accepted: 27 Sep 2021
ePublished: 29 Sep 2021
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