Kamran Hosseini
1,2 
, Hossein Ahangari
3, Florence Chapeland-leclerc
4, Gwenael Ruprich-Robert
4, Vahideh Tarhriz
5* , Azita Dilmaghani
6,7* 1 Department of Molecular Medicine, Faculty of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
3 Department of Food Science and Technology, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Université de Paris, Faculté des Sciences, Laboratoire Interdiciplinaire des Energies de Demain (LIED), UMR 8236 CNRS, F-75013, Paris, France.
5 Molecular Medicine Research Center, Bio-Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
6 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
7 Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract
Cancer is a serious debilitating disease and one of the most common causes of death. In recentdecades the high risk of various cancers enforced scientists to discover novel prevention andtreatment methods to diminish the mortality of this terrifying disease. Accordingly, its preventioncan be possible in near future. Based on epidemiological evidence, there is a clear link betweenpathogenic fungal infections and cancer development. This association is often seen in peoplewith weakened immune systems such as the elderly and people with acquired immunodeficiency(AIDS). Carcinoma in these people is first seen chronically and then acutely. Although thedifferent genetic and environmental risk factors are involved in carcinogenesis, one of the mostimportant risk factors is fungal species and infections associating with cancers etiology. Now itis known that microbial infection is responsible for initiating 2.2 million new cancer cases. Inthis way, many recent studies have focused on investigating the role and mechanism of fungalinfections in diverse cancers occurrence. This review provides a comprehensive frameworkof the latest clinical findings and the association of fungal infections with versatile cancersincluding esophageal, gastric, colorectal, lung, cervical, skin, and ovarian cancer.