Hayder Kadhim Drais
1* 
, Ahmed Abbas Hussein
2 1 Ministry of Health and Environment, Babil Health Directorate, Babil, Iraq.
2 Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq.
Abstract
Purpose: Felodipine, is a calcium-channel antagonist used for hypertension and anginapectoris. It is practically insoluble in aqueous media and shows low oral bioavailability (15%-20%). This investigation aims to prepare and characterize oral felodipine lipid-polymer hybridnanocarriers (LPHNs) to increase solubility and control delivery for increasing bioavailabilityand enhance patient compliance.Methods: The newly microwave-based method was prepared with felodipine LPHNs (H1-H35)successfully. The (H1-H35) were subjected to thermodynamic stability experiments. After that,select nine felodipine LPHNs (F1-F9) that have smart physical stability for further optimizationof different characterization processes.Results: The felodipine LPHNs (F4) are considered the most optimized formula. It wascharacterized by lower particle size (33.3 nm), lower PDI (0.314), high zeta potential (13.6mV), entrapment efficiency is (81.645% w/w), drug loading is (16.329% w/w), the pH value is4, excellent percent of light transmittance (95.5%), pseudoplastic rheogram, significantly high(P < 0.05) dissolution rate with sustained drug delivery and success ex-vivo intestinal permeationattributes. The (F4) subject for further investigations of Fourier transformed infrared spectroscopy(FTIR), atomic force microscopy (AFM), and transmission electron microscopy (TEM). The resultsof FTIR, AFM, and TEM indicate there is no interaction between the felodipine and excipientsand that the particulate system in the nanoscale dispersion system confirms the high stability.Conclusion: The optimized felodipine LPHNs (F1-F9) formulations were smart formulations forsustained oral delivery of felodipine and that F4 was the most optimized formula according toits characterization processes.