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Adv Pharm Bull. 2024;14(1): 67-85.
doi: 10.34172/apb.2024.018
  Abstract View: 492
  PDF Download: 398

Review Article

Transdermal Drug Delivery Systems: A Focused Review of the Physical Methods of Permeation Enhancement

Rifath Sheikh Vaseem 1 ORCID logo, Alison D’cruz 1, Srishti Shetty 1, Hafsa - 1, Aditya Vardhan 1, Shreya Shenoy R 1, Shirleen Miriam Marques 1, Lalit Kumar 1,2* ORCID logo, Ruchi Verma 3

1 Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576 104, Udupi, Karnataka, India.
2 Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hajipur 844 102, Vaishali, Bihar, India.
3 Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576 104, Udupi, Karnataka, India.
*Corresponding Author: Lalit Kumar, Email: lk.kundlas@gmail.com

Abstract

The skin is the body’s largest organ and serves as a site of administration for various medications. Transdermal drug delivery systems have several advantages over traditional delivery systems. It has both local and systemic therapeutic properties. Controlled plasma drug levels, reduced dosing frequency, and avoidance of hepatic first-pass metabolism are just a few of these systems’ advantages. To achieve maximum efficacy, it is critical to understand the kinetics, physiochemical properties of the drug moiety, and drug transport route. This manuscript focused on the principles of various physical means to facilitate transdermal drug delivery. Some examples are iontophoresis, electrophoresis, photomechanical waves, ultrasound, needleless injections, and microneedles. Mechanical, chemical, magnetic, and electrical energy are all used in physical methods. A major advantage of physical methods is their capability to abbreviate pain, which can be used for effective disease management. Further investigation should be carried out at the clinical level to understand these methods for effective drug delivery.
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Submitted: 25 Jan 2022
Revision: 07 Jul 2023
Accepted: 08 Oct 2023
ePublished: 14 Oct 2023
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