Adv Pharm Bull. 2024;14(1): 132-146.
doi: 10.34172/apb.2023.080
  Abstract View: 498
  PDF Download: 315

Review Article

Erythrocytes Nanoparticle Delivery: A Boon for Targeting Tumor

Adnan Rehmatullah Siddique 1* ORCID logo, Geeta Sameer Bhagwat 2 ORCID logo

1 Pharmaceutics Department, HK College of Pharmacy Mumbai 400102, India.
2 Pharmaceutics Department, DY Patil University School of Pharmacy, Sector-7, Nerul, Navi Mumbai 400706, India.
*Corresponding Author: Adnan Rehmatullah Siddique, Email: adnan.siddique@hkcp.edu.in


Although nanoparticles (NPs) have many advantages as drug delivery systems, their poor stability in circulation, premature drug release, and nonspecific uptake in non-target organs have prompted biomimetic approaches to camouflage nano vehicles using natural cell membranes. Among them, which are extensively studied in erythrocytes, are the most abundant circulating blood cells. They are specially used for biomimetic coating on artificial NPs due to their excellent properties of good biocompatibility, biodegradability, non-immunogenicity, and long-term blood circulation. Erythrocyte-mimicking nanoparticles (EM-NPs) are prepared by combining nanoparticle cores with naturally derived erythrocyte (red blood cell or RBC) membranes. Compared with conventional nanosystems, EM-NPs hold the preferable characteristics of prolonged blood circulation time and immune evasion. In this review, the biomimetic platform of erythrocyte membrane-coated NPs is described in various aspects, with particular focus placed on the coating mechanism, preparation methods, characterization method, and recent advances in the biomedical applications of EM-NPs concerning cancer and targeted delivery.
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Submitted: 08 May 2022
Revision: 14 Jan 2023
Accepted: 24 Apr 2023
ePublished: 29 Apr 2023
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