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Adv Pharm Bull. 2024;14(1): 147-160.
doi: 10.34172/apb.2024.019
  Abstract View: 647
  PDF Download: 519

Mini Review

Potential Applications of Mitochondrial Therapy with a Focus on Parkinson’s Disease and Mitochondrial Transplantation

Pranay Wal 1* ORCID logo, Ankita Wal 1, Himangi Vig 1, Danish Mahmood 2, Mohd Masih Uzzaman Khan 3 ORCID logo

1 Pharmacy Department, PSIT- Pranveer Singh Institute of Technology, (PHARMACY) Kanpur-Agra-Delhi National Highway (NH-2), Bhauti-Kanpur-209305.
2 Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Unaizah 51911, Saudi Arabia.
3 Department of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy, Unaizah 51911, Saudi Arabia.
*Corresponding Author: Pranay Wal, Email: pranaywal@gmail.com

Abstract

Purpose: Both aging and neurodegenerative illnesses are thought to be influenced by mitochondrial malfunction and free radical formation. Deformities of the energy metabolism, mitochondrial genome polymorphisms, nuclear DNA genetic abnormalities associated with mitochondria, modifications of mitochondrial fusion or fission, variations in shape and size, variations in transit, modified mobility of mitochondria, transcription defects, and the emergence of misfolded proteins associated with mitochondria are all linked to Parkinson’s disease.

Methods: This review is a condensed compilation of data from research that has been published between the years of 2014 and 2022, using search engines like Google Scholar, PubMed, and Scopus.

Results: Mitochondrial transplantation is a one-of-a-kind treatment for mitochondrial diseases and deficits in mitochondrial biogenesis. The replacement of malfunctioning mitochondria with transplanted viable mitochondria using innovative methodologies has shown promising outcomes as a cure for Parkinson’s, involving tissue sparing coupled with enhanced energy generation and lower oxidative damage. Numerous mitochondria-targeted therapies, including mitochondrial gene therapy, redox therapy, and others, have been investigated for their effectiveness and potency.

Conclusion: The development of innovative therapeutics for mitochondria-directed treatments in Parkinson’s disease may be aided by optimizing mitochondrial dynamics. Many neurological diseases have been studied in animal and cellular models, and it has been found that mitochondrial maintenance can slow the death of neuronal cells. It has been hypothesized that drug therapies for neurodegenerative diseases that focus on mitochondrial dysfunction will help to delay the onset of neuronal dysfunction.

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Abstract View: 648

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PDF Download: 519

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Submitted: 14 Mar 2023
Revision: 28 Jun 2023
Accepted: 08 Oct 2023
ePublished: 14 Oct 2023
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