Muyiwa S. Adegbaju
1,2 
, Ifeoluwa E. Adegbaju
3, Memunat A. Issah
4, Fatimatou Saccoh
5, Ademola A. Falade
3, James R. lloyd
1, Olanrewaju B. Morenikeji
5* 1 Institute of Plant Biotechnology, Stellenbosch University, Stellenbosch, South Africa
2 Department of Biomedical Sciences, Rochester Institute of Technology 153 Lomb Memorial Drive Rochester NY 14623, Rochester, USA
3 Department of Nutrition and Dietetics, Federal University of Technology Akure, Akure, Nigeria
4 Department of Biochemistry, Faculty of Chemical and Life Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
5 Division of Biological and Health Sciences, University of Pittsburgh at Bradford, Bradford, PA, United States
Abstract
The prevalence of nutrition-related non-communicable diseases like diabetes mellitus (DM) is exponentially increasing across the world. Particularly, type-2 diabetes mellitus (T2DM) is prevalent in sub-Saharan Africa (SSA) than in any other region of the world, with a significant effect on mortality and morbidity. T2DM is a disease known to be associated with elevated glucose levels in the blood, caused by numerous factors including dietary and lifestyle changes. Ensuring an adequate supply of a healthy diet through a transformed food system could be a potential strategy to mitigate T2DM in SSA. In plants, starch is the most common storage carbohydrate, and it is the major glucose-releasing carbohydrate in human diets. The rate of starch digestibility varies and is largely due to the proportion of its two polyglucan components, amylose and amylopectin. Although, no medication has been found to effectively treat T2DM, it could be managed through effective postprandial glycemia control. This article reviews the mechanism for slowing down the rate of starch digestion and absorption in the small intestine through direct alteration of amylose and amylopectin in starch crops. This strategy would ensure the supply of healthy diets for consumption and ultimately help to curb the increasing prevalence of T2DM.