Logo-apb
Submitted: 08 Oct 2024
Revision: 31 May 2025
Accepted: 01 Jun 2025
ePublished: 02 Jun 2025
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Adv Pharm Bull. Inpress.
doi: 10.34172/apb.025.43855
  Abstract View: 17

Review Article

M2 macrophages-based immunotherapy: A new therapeutic approach in liver fibrosis

Wahyu Widowati* ORCID logo, Adilah Hafizha Nur Sabrina, Annisa Firdaus Sutendi, Fadhilah Haifa Zahiroh, Teresa Liliana Wargasetia, Ita Margaretha Nainggolan, Elham Rismani* ORCID logo, Massoud Vosough* ORCID logo
*Corresponding Authors: Email: wahyu_w60@yahoo.com; Email: el.rismani@gmail.com; Email: masvos@royaninstitute.org

Abstract

Liver fibrosis (LF) is a pathological condition resulting from a chronic inflammatory response to multiple etiological factors, including viral infections, excessive alcohol consumption, and metabolic disorders. The important role of macrophages in this process, especially the M2 subtype, has attracted attention as a potential target for macrophage-based immunotherapy. M2 macrophages have anti-inflammatory and reparative properties that enable them to modulate the immune response and facilitate repairing damaged tissues. They participate in reducing fibrogenic features in term of gene expression and histological markers associated with LF. These cells phagocytose apoptotic cells and matrix components. M2 macrophage-based immunotherapy has shown great potential in ameliorating LF through mechanisms involving the IL-10/STAT3 and TGF-β/SMAD signaling pathways, which are essential in suppressing the pro-inflammatory response and supporting tissue regeneration. However, significant challenges such as individual resistance to therapy and the potential for promoting fibrosis suggest that further development and research are needed to optimize the safety and efficacy of this therapy in clinical applications. This study provides comprehensive insights into the role of M2 macrophages in LF and explores their potential as an innovative therapeutic approach in treating LF.
First Name
Last Name
Email Address
Comments
Security code


Abstract View: 17

Your browser does not support the canvas element.


PDF Download: 0

Your browser does not support the canvas element.