Abstract
Wound healing is a complex, multifactorial biological process encompassing cellular migration, modulation of inflammatory responses, and tissue remodeling. Despite significant progress in conventional therapeutic approaches, delayed or incomplete wound closure remains a prevalent clinical challenge. This review provides a comprehensive analysis of recent advancements in nanotechnology-driven strategies for wound management, emphasizing their underlying mechanisms, therapeutic benefits, and translational potential. A systematic literature search was conducted across electronic databases, including PubMed and Scopus, covering publications from 2000 to 2025. Studies focusing on nanomaterials, drug delivery platforms, and wound care interventions were prioritized. Nanotechnology offers innovative modalities that enhance drug delivery precision, stimulate angiogenesis, regulate inflammatory pathways, and mitigate microbial contamination. Diverse nanostructures—such as metallic nanoparticles, polymeric carriers, liposomes, and nanofibers—have demonstrated promising efficacy in both preclinical and clinical settings. Current evidence suggests that integrating nanotechnology into wound care holds substantial promise for accelerating tissue repair and improving regenerative outcomes. However, further research is warranted to address long-term safety, scalable manufacturing processes, and clinical validation through large-scale trials.