Abstract View: 90

Research Article

Topical Gel of Vitamin A Solid Lipid Nanoparticles: A Hopeful Promise as a Dermal Delivery System

Mahshid Boskabadi ORCID logo, Majid Saeedi* ORCID logo, Jafar Akbari, Katayoun Morteza-Semnani, Seyyed Mohammad Hassan Hashemi, Amirhossein Babaei ORCID logo


Purpose: The Objective of the present investigation was to enhance the skin delivery of Vitamin A (Vit A) via producing solid lipid nanoparticles (SLNs) through ultrasonication technique. Methods: For achieving optimal skin delivery, impacts of two surfactants ratio of Tween80:Span80 on nanoparticles (NPs) features and the respective functions were examined. Powder X-ray Diffractometer (PXRD), photon correlation spectroscopy, Attenuated Total Reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), Transmission electron microscopy (TEM), and differential scanning calorimetry (DSC) were applied for characterizing the solid state of Vit A in the SLN. Results: Results showed that size of the NPs is usually enhanced by adding co-emulsifier (Span80). Notably, minimum NPs size (64.85±4.259 nm) was achieved while the hydrophilic-lipophilic balance (HLB) of the binary surfactants was 12.08, close to bees-wax (BW) HLB (12) as lipid matrix. Also, maximum entrapment efficiency (66.01±8.670%) was observed in the formulation. DSC thermogram indicated an amorphous form of Vit A in SLN. ATR-FTIR spectra of Vit A-SLN illustrated that prominent functional groups are found in the formulations that might be a sign of acceptable entrapment of Vit A in a lipid matrix. Moreover, ATR-FTIR studies showed no chemical interactions between Vit A and excipients. Skin irritation test proved the non-irritancy of Vit A-SLN2, when applied to the dorsal region of Wistar rats. Finally, any cellular toxicity was not seen for NPs. Conclusion: It was found that the procured Vit A-SLNs could be utilized as potent carriers for the dermal delivery of Vit A.
Keywords: Vitamin A, solid lipid nanoparticle, dermal delivery, skin irritation
First Name
Last Name
Email Address
Security code

Abstract View: 90

Your browser does not support the canvas element.

PDF Download: 0

Your browser does not support the canvas element.

Submitted: 15 Apr 2020
Revision: 02 Sep 2020
Accepted: 03 Oct 2020
ePublished: 03 Oct 2020
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)