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Research Article

In vitro Assessment of Magnetic Liposomal Paclitaxel Nanoparticles as a Potential Carrier for the Treatment of Ovarian Cancer

Sara Yousefi Aldashi 1 ORCID logo, Zahra Saffari 2, Hasan Ebrahimi Shahmabadi 3* ORCID logo, Azim Akbarzadeh 2* ORCID logo

1 Islamic Azad University Faculty of Technical and Engineering, Science and Research Branch, Tehran, Iran.
2 Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.
3 Department of Microbiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Abstract

Purpose: This study aimed to evaluate the role of magnetic liposome nanoparticles (ML NPs) as a carrier for paclitaxel (PTX) for the treatment of ovarian cancer in vitro.
Methods: Magnetic NPs (MNPs) were synthesized by chemical co-precipitation method. The resulting NPs were characterized in terms of size, size distribution, zeta potential, drug encapsulation efficiency, drug release pattern, and cytotoxicity effects.
Results: The size and zeta potential of PTX-PEG-L and PTX-PEG-ML NPs were determined to be 296, 198 nm; -20, and -19 mV, respectively. Also, their drug encapsulation efficiencies were determined to be 97 and 96%, respectively. It was found that PTX-PEG-ML NPs, compared to PTX-PEG-L NPs, caused a reduction (11 %) in the rate of drug release. The cytotoxicity of the drug-loaded NPs was assessed using 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay against human ovarian epithelial cancer (A2780CP) cells, and the results demonstrated that PTX-PEG-ML NPs caused higher cytotoxicity (by 14%) compared to PTX-PEG-L NPs (IC50: 1.88 ± 0.09 and 2.142 ± 0.1 µM, respectively).
Conclusion: Overall, the results of this study suggest that PTX-PEG-ML NPs could be considered as a therapeutic candidate for the treatment of ovarian cancer.
Keywords: Cytotoxicity, Drug delivery, Magnetic liposome, Nanoparticles, Ovarian cancer, Paclitaxel
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Submitted: 14 May 2020
Revision: 29 Jul 2020
Accepted: 05 Aug 2020
ePublished: 05 Aug 2020
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