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Short Communication

Physical Characterization and Biodistribution of Cisplatin Loaded in Surfactant Modified-Hybrid Nanoparticles using Polyethylene Oxide-b-Polymethacrylic Acid

Andang Miatmoko* ORCID logo

Abstract

Purpose: Conjugating cisplatin into hybrid nanoparticles is intended to enhance tumor accumulation due to drug interaction with polymer and prevent premature drug release because of the presence of a lipid layer. Methods: Hybrid nanoparticles composed of polyethylene oxide-b-polymethacrylic acid, egg phosphatidylcholine, and surfactant, i.e. sodium cholate/sodium deoxycholate/Tween 80, were prepared by the injection method. Cisplatin was subsequently loaded by incubating the polymer-drug mixtures at the molar ratio of carboxylate ions of 2:1. Results: The results showed that the addition of surfactants produced particle sizes between 33 and 52 nm. The addition of cisplatin increased the ζ-potential to slightly positive charges with encapsulation efficiencies of 5-18%. An in vivo biodistribution study of mice identified a cisplatin plasma concentration of sodium cholate-modified hybrid nanoparticles ten times higher than cisplatin solution, thus producing high tumor accumulation. Conclusion: Conjugating cisplatin into sodium cholate-modified hybrid nanoparticles improves its accumulation in tumors.
Keywords: cisplatin, egg phosphatidylcholine, hybrid nanoparticles, polyethylene oxide-b-polymethacrylic acid, surfactants
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Submitted: 25 May 2020
Revision: 05 Aug 2020
Accepted: 17 Oct 2020
ePublished: 20 Oct 2020
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