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  Abstract View: 54

Letter to Editor

Proteomics in Host-Protozoan Parasite Interactions and Development of Drug and Vaccine

Awanish Kumar* ORCID logo

1 Department of Biotechnology, National Institute of Technology Raipur, Raipur – 492010, Chhattisgarh (INDIA).

Abstract

Protozoan parasites that cause disease in humans (Leishmania, Plasmodium, Trypanosoma) reflect the balance of host defenses and pathogen virulence at the time of invasion to the host. They have evolved a variety of strategies to subvert host defense functions. Proteomic technologies provide an opportunity to know the involvement of the protein in the pathogenesis. With the help of proteomics tools, it is now possible to characterize host-protozoan parasite interactions. The outcome of this interaction is dependent on the gene/protein expression of parasite that establishes the infection to the host. Advances in proteomics are now providing the opportunity to study gene/protein of complex parasite biologic systems responsible for the infection. Proteomics-based approach and understanding of host-protozoan parasite interaction have the potential to improve mechanistic understanding of virulence and pathogenicity of Leishmania, Plasmodium, and Trypanosoma because proteomics could identify virulence-associated proteins of the parasite with for defining novel therapeutic targets and vaccine candidates. Proteomic characterization of the host response can provide protozoan parasite-specific biomarkers for the explicit and rapid detection of these parasites. Overall proteomics would be a good thought for host-protozoan parasite interactions and the development of drug/vaccine against various protozoan infections.
Keywords: Proteomics, host-protozoan interactions, target, drug/vaccine development
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Submitted: 31 May 2020
Revision: 10 Jul 2020
Accepted: 15 Jul 2020
ePublished: 15 Jul 2020
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