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Adv Pharm Bull. 2022;12(3): 424-436.
doi: 10.34172/apb.2022.047
PMID: 35935044
PMCID: PMC9348543
Scopus ID: 85140272341
  Abstract View: 763
  PDF Download: 437
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Review Article

Novel Chronic Wound Healing by Anti-biofilm Peptides and Protease

Fatemeh Sadat Ghoreishi ORCID logo, Rasoul Roghanian* ORCID logo, Giti Emtiazi ORCID logo

1 Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
*Corresponding Author: Corresponding Author: Rasoul Roghanian, Tel: +98 311 7932458, Fax: +98 311 7932456, Email: , Email: r.roghanian@sci.ui.ac.ir

Abstract

Chronic wounds have made a challenge in medical healthcare due to their biofilm infections, which reduce the penetrance of the antibacterial agents in the injury site. In infected wounds, the most common bacterial strains are Staphylococcus aureus and Pseudomonas aeruginosa. Biofilm disruption in chronic wounds is crucial in wound healing. Due to their broad-spectrum antibacterial properties and fewer side effects, anti-biofilm peptides, especially bacteriocins, are promising in the healing of chronic wounds by biofilm destruction. This study reviews the effects of antimicrobial and anti-biofilm agents, including bacteriocins and protease enzymes as a novel approach, on wound healing, along with analyzing the molecular docking between a bacterial protease and biofilm components. Among a large number of anti-biofilm bacteriocins identified up to now, seven types have been registered in the antimicrobial peptides (AMPs) database. Although it is believed that bacterial proteases are harmful in wound healing, it has recently been demonstrated that these proteases like the human serine protease, in combination with AMPs, can improve wound healing by biofilm destruction. In this work, docking results between metalloprotease from Paenibacillus polymyxa and proteins of S. aureus and P. aeruginosa involved in biofilm production, showed that this bacterial protease could efficiently interact with biofilm components. Infected wound healing is an important challenge in clinical trials due to biofilm production by bacterial pathogens. Therefore, simultaneous use of proteases or anti-biofilm peptides with antimicrobial agents could be a promising method for chronic wound healing.
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Submitted: 10 Nov 2020
Revision: 23 Jan 2021
Accepted: 25 Mar 2021
ePublished: 27 Mar 2021
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