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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2017;7(2): 229-239. doi: 10.15171/apb.2017.028
PMID: 28761825        PMCID: PMC5527237

Research Article

Gellified Emulsion of Ofloxacin for Transdermal Drug Delivery System

Swati Jagdale 1 * , Saylee Pawar 1

Cited by CrossRef: 33

1- Mahmood H, Khan I, Asif M, Khan R, Asghar S, Khalid I, Khalid S, Irfan M, Rehman F, Shahzad Y, Yousaf A, Younus A, Niazi Z, Asim M. In vitro and in vivo evaluation of gellan gum hydrogel films: Assessing the co impact of therapeutic oils and ofloxacin on wound healing. International Journal of Biological Macromolecules. 2021;166:483 [Crossref]
2- Mohammadi-Samani S, Masoumzadeh P, Ghasemiyeh P, Alipour S. Oxybutynin-Nanoemulgel Formulation as a Successful Skin Permeation Strategy: In-vitro and ex-vivo Evaluation. Front Mater. 2022;9 [Crossref]
3- Fitria Apriani E, Shiyan S, Hardestyariki D, Starlista V, Laras Sari A. Optimization of Hydroxypropyl Methylcellulose (HPMC) and Carbopol 940 in Clindamycin HCl Ethosomal Gel as Anti-acne. RJPT. 2024;:603 [Crossref]
4- Bagińska Z, Paczkowska-Walendowska M, Basa A, Rachalewski M, Lendzion K, Cielecka-Piontek J, Szymańska E. Chitosan/Pomegranate Seed Oil Emulgel Composition as a New Strategy for Dermal Delivery of Hydrocortisone. IJMS. 2024;25(7):3765 [Crossref]
5- Ferreira I, Marques A, Costa P, Amaral M. Effects of Steam Sterilization on the Properties of Stimuli-Responsive Polymer-Based Hydrogels. Gels. 2023;9(5):385 [Crossref]
6- Moreira L, Oliveira A, Chaves L, Soares M, Soares‐Sobrinho J. From Challenges to Solution: The Evolving Landscape of Leprosy Management. Advanced Therapeutics. 2024;7(12) [Crossref]
7- Ogedengbe O, Kolawole O. Formulation and evaluation of fluconazole emulgels for potential treatment of vaginal candidiasis. Heliyon. 2024;10(6):e28206 [Crossref]
8- Zhang J, Han J, Zhu A, Zhu X, Zeng Y, Yin M, Xiao Y, Wang C, Yin C, Wang X, Zhang G, Hao C. Development and Evaluation of an Innovative S‐Flurbiprofen‐Diethylamine Emulgel With Superior Transdermal Delivery and Analgesic Activity. J Biomedical Materials Res. 2025;113(7) [Crossref]
9- Jagdale S, Brahmane S, Chabukswar A. Optimization of Microemulgel for Tizanidine Hydrochloride. AIAAMC. 2020;19(2):158 [Crossref]
10- Zafar A, Yasir M, Khalid M. Development of Piperine-Loaded Soft Binary Ethosomal Gel to Improve Transdermal Delivery: Box-Bhekhen Design Optimization, Ex-Vivo Permeation, and Antimicrobial Evaluation. J Clust Sci. 2024;35(1):311 [Crossref]
11- Botega D, Nogueira C, de Moura N, Martinez R, Rodrigues C, Barrera‐Arellano D. Influence of Aqueous Matrices into Candelilla Wax Organogels Emulsions for Topical Applications. J Americ Oil Chem Soc. 2021;98(3):317 [Crossref]
12- Zamir A, Rasool M, Hussain I, Alsanea S, Alhabardi S, Alqahtani F. A Comprehensive Physiologically Based Pharmacokinetic Framework of Ofloxacin: Predicting Disposition in Renal Impairment. Pharmaceutics. 2025;17(9):1224 [Crossref]
13- Alsheikh R, Haimhoffer Á, Nemes D, Ujhelyi Z, Fehér P, Józsa L, Vasvári G, Pető Á, Kósa D, Nagy L, Horváth L, Balázs B, Bácskay I. Formulation of Thermo-Sensitive In Situ Gels Loaded with Dual Spectrum Antibiotics of Azithromycin and Ofloxacin. Polymers. 2024;16(21):2954 [Crossref]
14- Rompicherla N, Joshi P, Shetty A, Sudhakar K, Amin H, Mishra Y, Mishra V, Albutti A, Alhumeed N. Design, Formulation, and Evaluation of Aloe vera Gel-Based Capsaicin Transemulgel for Osteoarthritis. Pharmaceutics. 2022;14(9):1812 [Crossref]
15- Suliman S, Othman N, Noah N, Kahar I. Extraction and enrichment of zinc from chloride media using emulsion liquid membrane: Emulsion stability and demulsification via heating-ultrasonic method. Journal of Molecular Liquids. 2023;374:121261 [Crossref]
16- Demirtürk E. In vitro evaluation of emulgel formulation for topical application of diclofenac potassium. 2024;49(2):371 [Crossref]
17- Otarbayeva S, Berillo D. Poly(Vinyl Alcohol) Drug and PVA–Drug–Surfactant Complex Organogel with Dimethyl Sulfoxide as a Drug Delivery System. Gels. 2024;10(11):753 [Crossref]
18- Sohail M, Naveed A, Abdul R, Abdul G, Muhammad Shoaib Khan H, Khan H. An approach to enhanced stability: Formulation and characterization of Solanum lycopersicum derived lycopene based topical emulgel. Saudi Pharmaceutical Journal. 2018;26(8):1170 [Crossref]
19- Kitisin T, Muangkaew W, Ampawong S, Sansurin N, Thitipramote N, Sukphopetch P. Development and efficacy of tryptophol-containing emulgel for reducing subcutaneous fungal nodules from Scedosporium apiospermum eumycetoma. 2022;17(6):707 [Crossref]
20- Malavi S, Kumbhar P, Manjappa A, Disouza J, Dwivedi J. Emulgel for improved topical delivery of Tretinoin: Formulation design and characterization. Annales Pharmaceutiques Françaises. 2022;80(2):157 [Crossref]
21- Jagdale S, Bafna M, Chabukswar A. Transdermal Anti-inflammatory Delivery for Solid Lipid Nanoparticles of Ketoprofen by Microwave-assisted Microemulsion. RAIAD. 2022;15(2):87 [Crossref]
22- Ojha B, Jain V, Gupta S, Talegaonkar S, Jain K. Nanoemulgel: a promising novel formulation for treatment of skin ailments. Polym Bull. 2022;79(7):4441 [Crossref]
23- Sakarkar S, Jagdale S, Dargude S, Chabukswar A, Urooj S, Bilal A, Mengash H. Optimization of Anthralin Microemulgel Targeted Delivery for Psoriasis and Acne. Molecules. 2025;30(12):2629 [Crossref]
24- Ahmad Shariff S, Daik R, Haris M, Ismail M. Hydrophobic Drug Carrier from Polycaprolactone-b-Poly(Ethylene Glycol) Star-Shaped Polymers Hydrogel Blend as Potential for Wound Healing Application. Polymers. 2023;15(9):2072 [Crossref]
25- Erum A, Tulain U, Malik N, Riaz A, Yaqoob M, Mahmood A, Rashid A, Shahid N, Gohar N, Malik A, Malik M, Tayyab M. Formulation and optimization of pectin-based emulgel isolated from Abelmoschus esculentus using response surface methodology. Polym Bull. 2024;81(11):10039 [Crossref]
26- Elsewedy H, Younis N, Shehata T, Mohamed M, Soliman W. Enhancement of Anti-Inflammatory Activity of Optimized Niosomal Colchicine Loaded into Jojoba Oil-Based Emulgel Using Response Surface Methodology. Gels. 2021;8(1):16 [Crossref]
27- Ma M, Liu Y, Chang H, Wang Y, Qiao Y. Investigation of the binding behavior of PAMAMs-NH2 dendrimers with ofloxacin via NMR studies. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2023;658:130625 [Crossref]
28- Zhang W, Zhao X, Yu G, Suo M. Optimization of propofol loaded niosomal gel for transdermal delivery. Journal of Biomaterials Science, Polymer Edition. 2021;32(7):858 [Crossref]
29- Rukari T, Gavali P, Patil V, Gaonakr S, Rathod K, Patil Y, Dhongade Y, Jagtap V. Innovative Vesicular Drug Delivery System of Ibuprofen with Unsaturated Fatty Acids: Formulation and Evaluation. AJPT. 2024;:319 [Crossref]
30- Salman H, Al-Zubaidy A, Abbas A, Zigam Q. The ameliorative effects of topical gemifloxacin alone or in combination with clobetasol propionate on imiquimod-induced model of psoriasis in mice. Naunyn-Schmiedeberg's Arch Pharmacol. 2024;397(1):599 [Crossref]
31- Coêlho E, Lopes G, Pinheiro I, Holanda J, Alves M, Carvalho Nogueira N, Carvalho F, Carvalho A. Emulgel based on amphotericin B and bacuri butter (Platonia insignisMart.) for the treatment of cutaneous leishmaniasis: characterization andin vitroassays. Drug Development and Industrial Pharmacy. 2018;44(10):1713 [Crossref]
32- Lu C, Dai Y, Tao Y, Yin Q, Jiang Y, Jiang T. Triptolide-Loaded Solid Lipid Nanogel: Preparation and In-Vitro Evaluation. j biomed nanotechnol. 2024;20(2):231 [Crossref]
33- Abdallah M, Elghamry H, Khalifa N, Khojali W, Khafagy E, Lila A, El-Horany H, El-Housiny S. Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity. Gels. 2022;8(11):737 [Crossref]
34- Raeisi Estabragh M, Sajadi Bami M, Dehghannoudeh G, Noudeh Y, Moghimipour E. Cellulose derivatives and natural gums as gelling agents for preparation of emulgel-based dosage forms: A brief review. International Journal of Biological Macromolecules. 2023;241:124538 [Crossref]
35- Burki I, Khan M, Khan B, Uzair B, Braga V, Jamil Q. Formulation Development, Characterization, and Evaluation of a Novel Dexibuprofen-Capsaicin Skin Emulgel with Improved In Vivo Anti-inflammatory and Analgesic Effects. AAPS PharmSciTech. 2020;21(6) [Crossref]
36- Abbas A, Abbood M, Ridha-Salman H, Fakhri S, Abbas Z, Al-Athari A. Suppressive effect of topical moxifloxacin on imiquimod-induced model of psoriasis in mice. Naunyn-Schmiedeberg's Arch Pharmacol. 2025; [Crossref]
37- Sharma M, Sharma G, Singh B, Katare O. Systematically Optimized Imiquimod-Loaded Novel Hybrid Vesicles by Employing Design of Experiment (DoE) Approach with Improved Biocompatibility, Stability, and Dermatokinetic Profile. AAPS PharmSciTech. 2019;20(4) [Crossref]
38- Kumar A, Sahani V, Patil S. Transdermal Patches: Design and Current Approaches Using Natural Polymers. J Res Appl Sci Biotechnol. 2024;3(5):285 [Crossref]
39- Pandey P, Minocha N, Vashist N, Shah R, Saini S, Makhija M, Purohit D, Kaushik D. Emulgel: An Emerging Approach towards Effective Topical Drug Delivery. DDL. 2022;12(4):227 [Crossref]
40- Meng S, Yu Y, Bu F, Yan C, Wu Z, Li Y. Directional Self-Assembly of Ofloxacin and Syringic Acid: The First Salt Cocrystal of Ofloxacin with Phenolic Acid Displays Superior In Vitro/Vivo Biopharmaceutical Property and Enhanced Antibacterial Activity. Crystal Growth & Design. 2022;22(11):6735 [Crossref]
41- Jain A, Kumar P, Verma A, Mohanta B, Ashique S, Pal R, Kumar S, Mishra N. Emulgel: A Cutting Edge Approach for Topical Drug Delivery System. CDRR. 2025;17(2):217 [Crossref]
42- Ali Z, Din F, Zahid F, Sohail S, Imran B, Khan S, Malik M, Zeb A, Khan G. RETRACTED ARTICLE: Transdermal delivery of allopurinol-loaded nanostructured lipid carrier in the treatment of gout. BMC Pharmacol Toxicol. 2022;23(1) [Crossref]