Adv Pharm Bull. 2015;5(3): 305-313. doi: 10.15171/apb.2015.043
PMID: 26504751        PMCID: PMC4616893

Review Article

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application


Cited by CrossRef: 79


1- Abdolahpour S, Mahdieh N, Jamali Z, Akbarzadeh A, Toliyat T, Paknejad M. Development of Doxorubicin-Loaded Nanostructured Lipid Carriers: Preparation, Characterization, and In Vitro Evaluation on MCF-7 Cell Line. BioNanoSci. 2017;7(1):32 [Crossref]
2- Tan A, Jeyaraj R, Ashkan K. Nanotechnology in neurosurgery: thinking small, dreaming big. British Journal of Neurosurgery. 2017;31(5):538 [Crossref]
3- Reichmuth A, Oberli M, Jaklenec A, Langer R, Blankschtein D. mRNA vaccine delivery using lipid nanoparticles. Therapeutic Delivery. 2016;7(5):319 [Crossref]
4- de Melo N, de Macedo C, Bonfante R, Abdalla H, da Silva C, Pasquoto T, de Lima R, Fraceto L, Clemente-Napimoga J, Napimoga M, Ahmad M. 15d-PGJ2-Loaded Solid Lipid Nanoparticles: Physicochemical Characterization and Evaluation of Pharmacological Effects on Inflammation. PLoS ONE. 2016;11(8):e0161796 [Crossref]
5- Da Silva C, Peters G, Ossendorp F, Cruz L. The potential of multi-compound nanoparticles to bypass drug resistance in cancer. Cancer Chemother Pharmacol. 2017;80(5):881 [Crossref]
6- Marques A, Rocha A, Leal P, Estanqueiro M, Lobo J. Development and characterization of mucoadhesive buccal gels containing lipid nanoparticles of ibuprofen. International Journal of Pharmaceutics. 2017;533(2):455 [Crossref]
7- Zhang D, Lee H, Wang X, Rai A, Groot M, Jin Y. Exosome-Mediated Small RNA Delivery: A Novel Therapeutic Approach for Inflammatory Lung Responses. Molecular Therapy. 2018;26(9):2119 [Crossref]
8- Khurana R, Bansal A, Beg S, Burrow A, Katare O, Singh K, Singh B. Enhancing biopharmaceutical attributes of phospholipid complex-loaded nanostructured lipidic carriers of mangiferin: Systematic development, characterization and evaluation. International Journal of Pharmaceutics. 2017;518(1-2):289 [Crossref]
9- Khosa A, Reddi S, Saha R. Nanostructured lipid carriers for site-specific drug delivery. Biomedicine & Pharmacotherapy. 2018;103:598 [Crossref]
10- Gupta B, Yong C, Kim J. Solid matrix-based lipid nanoplatforms as carriers for combinational therapeutics in cancer. Journal of Pharmaceutical Investigation. 2017;47(6):461 [Crossref]
11- Patil T, Deshpande A, Deshpande S, Shende P. Targeting pulmonary tuberculosis using nanocarrier-based dry powder inhalation: current status and futuristic need. Journal of Drug Targeting. 2019;27(1):12 [Crossref]
12- Badri W, Miladi K, Nazari Q, Greige-Gerges H, Fessi H, Elaissari A. Encapsulation of NSAIDs for inflammation management: Overview, progress, challenges and prospects. International Journal of Pharmaceutics. 2016;515(1-2):757 [Crossref]
13- Chanburee S, Tiyaboonchai W. Enhanced intestinal absorption of curcumin in Caco-2 cell monolayer using mucoadhesive nanostructured lipid carriers. J Biomed Mater Res. 2018;106(2):734 [Crossref]
14- Mvango S, Matshe W, Balogun A, Pilcher L, Balogun M. Nanomedicines for Malaria Chemotherapy: Encapsulation vs. Polymer Therapeutics. Pharm Res. 2018;35(12) [Crossref]
15- Miranda A, Blanco-Prieto M, Sousa J, Pais A, Vitorino C. Breaching barriers in glioblastoma. Part II: Targeted drug delivery and lipid nanoparticles. International Journal of Pharmaceutics. 2017;531(1):389 [Crossref]
16- Teeranachaideekul V, Chantaburanan T, Junyaprasert V. Influence of state and crystallinity of lipid matrix on physicochemical properties and permeation of capsaicin-loaded lipid nanoparticles for topical delivery. Journal of Drug Delivery Science and Technology. 2017;39:300 [Crossref]
17- Feng H, Zhu Y, Fu Z, Li D. Preparation, characterization, and in vivo study of rhein solid lipid nanoparticles for oral delivery. Chem Biol Drug Des. 2017;90(5):867 [Crossref]
18- Chanburee S, Tiyaboonchai W. Mucoadhesive nanostructured lipid carriers (NLCs) as potential carriers for improving oral delivery of curcumin. Drug Development and Industrial Pharmacy. 2017;43(3):432 [Crossref]
19- Zeeshan F, Tabbassum M, Jorgensen L, Medlicott N. Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) Spectroscopy as an Analytical Method to Investigate the Secondary Structure of a Model Protein Embedded in Solid Lipid Matrices. Appl Spectrosc. 2018;72(2):268 [Crossref]
20- Charlie-Silva I, Fraceto L, de Melo N. Progress in nano-drug delivery of artemisinin and its derivatives: towards to use in immunomodulatory approaches. Artificial Cells, Nanomedicine, and Biotechnology. 2018;:1 [Crossref]
21- Wang F, Chen J, Dai W, He Z, Zhai D, Chen W. Pharmacokinetic studies and anticancer activity of curcumin-loaded nanostructured lipid carriers. 2017;67(3):357 [Crossref]
22- Zununi Vahed S, Salehi R, Davaran S, Sharifi S. Liposome-based drug co-delivery systems in cancer cells. Materials Science and Engineering: C. 2017;71:1327 [Crossref]
23- Sergeeva O, Koteliansky V, Zatsepin T. mRNA-based therapeutics–Advances and perspectives. Biochemistry Moscow. 2016;81(7):709 [Crossref]
24- Dean S, Turner K, Medintz I, Walper S. Targeting and delivery of therapeutic enzymes. Therapeutic Delivery. 2017;8(7):577 [Crossref]
25- Zielińska A, Martins-Gomes C, Ferreira N, Silva A, Nowak I, Souto E. Anti-inflammatory and anti-cancer activity of citral: Optimization of citral-loaded solid lipid nanoparticles (SLN) using experimental factorial design and LUMiSizer®. International Journal of Pharmaceutics. 2018;553(1-2):428 [Crossref]
26- Sengupta S, Balla V. A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment. Journal of Advanced Research. 2018;14:97 [Crossref]
27- Dal Magro R, Ornaghi F, Cambianica I, Beretta S, Re F, Musicanti C, Rigolio R, Donzelli E, Canta A, Ballarini E, Cavaletti G, Gasco P, Sancini G. ApoE-modified solid lipid nanoparticles: A feasible strategy to cross the blood-brain barrier. Journal of Controlled Release. 2017;249:103 [Crossref]
28- Shen M, Liu T, Yu T, Kv R, Chiang W, Tsai Y, Chen H, Lin S, Chiu H. Hierarchically targetable polysaccharide-coated solid lipid nanoparticles as an oral chemo/thermotherapy delivery system for local treatment of colon cancer. Biomaterials. 2019;197:86 [Crossref]
29- Sengupta S, Khatua C, Balla V. In Vitro Carcinoma Treatment Using Magnetic Nanocarriers under Ultrasound and Magnetic Fields. ACS Omega. 2018;3(5):5459 [Crossref]
30- Ioele G, Tavano L, Luca M, Muzzalupo R, Mancuso A, Ragno G. Light-sensitive drugs in topical formulations: stability indicating methods and photostabilization strategies. Future Medicinal Chemistry. 2017;9(15):1795 [Crossref]
31- Zhao Y, Chang Y, Hu X, Liu C, Quan L, Liao Y. Solid lipid nanoparticles for sustained pulmonary delivery of Yuxingcao essential oil: Preparation, characterization and in vivo evaluation. International Journal of Pharmaceutics. 2017;516(1-2):364 [Crossref]
32- Lembo D, Donalisio M, Civra A, Argenziano M, Cavalli R. Nanomedicine formulations for the delivery of antiviral drugs: a promising solution for the treatment of viral infections. Expert Opinion on Drug Delivery. 2018;15(1):93 [Crossref]
33- Mittal R, Patel A, Jhaveri V, Kay S, Debs L, Parrish J, Pan D, Nguyen D, Mittal J, Jayant R. Recent advancements in nanoparticle based drug delivery for gastrointestinal disorders. Expert Opinion on Drug Delivery. 2018;15(3):301 [Crossref]
34- Madni A, Batool A, Noreen S, Maqbool I, Rehman F, Kashif P, Tahir N, Raza A. Novel nanoparticulate systems for lung cancer therapy: an updated review. Journal of Drug Targeting. 2017;25(6):499 [Crossref]
35- Jeong S, Jang J, Cho H, Lee Y. Soft- and hard-lipid nanoparticles: a novel approach to lymphatic drug delivery. Arch Pharm Res. 2018;41(8):797 [Crossref]
36- Bardania H, Tarvirdipour S, Dorkoosh F. Liposome-targeted delivery for highly potent drugs. Artificial Cells, Nanomedicine, and Biotechnology. 2017;45(8):1478 [Crossref]
37- Tapeinos C, Battaglini M, Ciofani G. Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases. Journal of Controlled Release. 2017;264:306 [Crossref]
38- Zeeshan F, Tabbassum M, Jorgensen L, Medlicott N. Investigation on Secondary Structure Perturbations of Proteins Embedded in Solid Lipid Matrices as a Novel Indicator of their Biological Activity upon In Vitro Release. AAPS PharmSciTech . 2018;19(2):769 [Crossref]
39- Castellani S, Trapani A, Spagnoletta A, di Toma L, Magrone T, Di Gioia S, Mandracchia D, Trapani G, Jirillo E, Conese M. Nanoparticle delivery of grape seed-derived proanthocyanidins to airway epithelial cells dampens oxidative stress and inflammation. J Transl Med. 2018;16(1) [Crossref]
40- Kaul S, Gulati N, Verma D, Mukherjee S, Nagaich U. Role of Nanotechnology in Cosmeceuticals: A Review of Recent Advances. Journal of Pharmaceutics. 2018;2018:1 [Crossref]
41- Martínez-Ballesta M, Gil-Izquierdo Á, García-Viguera C, Domínguez-Perles R. Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health. Foods. 2018;7(5):72 [Crossref]
42- Zhang W, Gu H, Li X, Li Y, Tang H, Tian G, Shang H. The dark side of “the force” – lipid nanoparticles enhance the oncogenesis of diethylnitrosamine and result in liver cancer in mice. Nanomedicine: Nanotechnology, Biology and Medicine. 2017;13(2):701 [Crossref]
43- Gao Y, Kraft J, Yu D, Ho R. Recent developments of nanotherapeutics for targeted and long-acting, combination HIV chemotherapy. European Journal of Pharmaceutics and Biopharmaceutics. 2018; [Crossref]
44- Raina H, Kaur S, Jindal A. Development of efavirenz loaded solid lipid nanoparticles: Risk assessment, quality-by-design (QbD) based optimisation and physicochemical characterisation. Journal of Drug Delivery Science and Technology. 2017;39:180 [Crossref]
45- Hibbitts A, O’Leary C. Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus. Materials. 2018;11(2):321 [Crossref]
46- Baldim I, Tonani L, von Zeska Kress M, Pereira Oliveira W. Lippia sidoides essential oil encapsulated in lipid nanosystem as an anti-Candida agent. Industrial Crops and Products. 2019;127:73 [Crossref]
47- Tran B, Nguyen H, Kim J, Yong C, Nguyen C. Combination of a chemopreventive agent and paclitaxel in CD44-targeted hybrid nanoparticles for breast cancer treatment. Arch Pharm Res. 2017;40(12):1420 [Crossref]
48- Gonçalves A, Nikmaram N, Roohinejad S, Estevinho B, Rocha F, Greiner R, McClements D. Production, properties, and applications of solid self-emulsifying delivery systems (S-SEDS) in the food and pharmaceutical industries. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2018;538:108 [Crossref]
49- Nitthikan N, Leelapornpisid P, Natakankitkul S, Chaiyana W, Mueller M, Viernstein H, Kiattisin K. Improvement of Stability and Transdermal Delivery of Bioactive Compounds in Green Robusta Coffee Beans Extract Loaded Nanostructured Lipid Carriers. Journal of Nanotechnology. 2018;2018:1 [Crossref]
50- Czajkowska-Kośnik A, Szekalska M, Winnicka K. Nanostructured lipid carriers: A potential use for skin drug delivery systems. Pharmacological Reports. 2019;71(1):156 [Crossref]
51- Marslin G, Siram K, Liu X, Khandelwal V, Shen X, Wang X, Franklin G. Solid Lipid Nanoparticles of Albendazole for Enhancing Cellular Uptake and Cytotoxicity against U-87 MG Glioma Cell Lines. Molecules. 2017;22(11):2040 [Crossref]
52- Hinger D, Navarro F, Käch A, Thomann J, Mittler F, Couffin A, Maake C. Photoinduced effects of m-tetrahydroxyphenylchlorin loaded lipid nanoemulsions on multicellular tumor spheroids. J Nanobiotechnol. 2016;14(1) [Crossref]
53- Shorter S, Gollings A, Gorringe-Pattrick M, Coakley J, Dyer P, Richardson S. The potential of toxin-based drug delivery systems for enhanced nucleic acid therapeutic delivery. Expert Opinion on Drug Delivery. 2017;14(5):685 [Crossref]
54- Meng Z, O'Keeffe-Ahern J, Lyu J, Pierucci L, Zhou D, Wang W. A new developing class of gene delivery: messenger RNA-based therapeutics. Biomater Sci. 2017;5(12):2381 [Crossref]
55- Wolfmeier H, Pletzer D, Mansour S, Hancock R. New Perspectives in Biofilm Eradication. ACS Infect Dis. 2018;4(2):93 [Crossref]
56- Nelson D, Pan Y, Tikekar R, Dan N, Nitin N. Compound Stability in Nanoparticles: The Effect of Solid Phase Fraction on Diffusion of Degradation Agents into Nanostructured Lipid Carriers. Langmuir. 2017;33(49):14115 [Crossref]
57- Saez V, Souza I, Mansur C. Lipid nanoparticles (SLN & NLC) for delivery of vitamin E: a comprehensive review. Int J Cosmet Sci. 2018;40(2):103 [Crossref]
58- Mi G, Shi D, Wang M, Webster T. Reducing Bacterial Infections and Biofilm Formation Using Nanoparticles and Nanostructured Antibacterial Surfaces. Adv Healthcare Mater. 2018;7(13):1800103 [Crossref]
59- Wong J, Mohseni R, Hamidieh A, MacLaren R, Habib N, Seifalian A. Will Nanotechnology Bring New Hope for Gene Delivery?. Trends in Biotechnology. 2017;35(5):434 [Crossref]
60- Movahedi F, Li L, Gu W, Xu Z. Nanoformulations of albendazole as effective anticancer and antiparasite agents. Nanomedicine. 2017;12(20):2555 [Crossref]
61- Abdelaziz H, Gaber M, Abd-Elwakil M, Mabrouk M, Elgohary M, Kamel N, Kabary D, Freag M, Samaha M, Mortada S, Elkhodairy K, Fang J, Elzoghby A. Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates. Journal of Controlled Release. 2018;269:374 [Crossref]
62- Chen X, Mangala L, Rodriguez-Aguayo C, Kong X, Lopez-Berestein G, Sood A. RNA interference-based therapy and its delivery systems. Cancer Metastasis Rev. 2018;37(1):107 [Crossref]
63- Ngan C, Asmawi A. Lipid-based pulmonary delivery system: a review and future considerations of formulation strategies and limitations. Drug Deliv and Transl Res. 2018;8(5):1527 [Crossref]
64- Huang J, Wang Q, Li T, Xia N, Xia Q. Nanostructured lipid carrier (NLC) as a strategy for encapsulation of quercetin and linseed oil: Preparation and in vitro characterization studies. Journal of Food Engineering. 2017;215:1 [Crossref]
65- Nothnagel L, Wacker M. How to measure release from nanosized carriers?. European Journal of Pharmaceutical Sciences. 2018;120:199 [Crossref]
66- Nadimi A, Ebrahimipour S, Afshar E, Falahati-pour S, Ahmadi Z, Mohammadinejad R, Mohamadi M. Nano-scale drug delivery systems for antiarrhythmic agents. European Journal of Medicinal Chemistry. 2018;157:1153 [Crossref]
67- Li Y, Liu R, Ji W, Li Y, Liu L, Zhang X. Delivery systems for theranostics in neurodegenerative diseases. Nano Res. 2018;11(10):5535 [Crossref]
68- Cortesi R, Esposito E, Drechsler M, Pavoni G, Cacciatore I, Sguizzato M, Di Stefano A. L-dopa co-drugs in nanostructured lipid carriers: A comparative study. Materials Science and Engineering: C. 2017;72:168 [Crossref]
69- El-Say K, Hosny K, Ahmad A. Optimization of carvedilol solid lipid nanoparticles: An approach to control the release and enhance the oral bioavailability on rabbits. PLoS ONE. 2018;13(8):e0203405 [Crossref]
70- Lim Y, Poh K, Loo S. Hybrid Janus Microparticles Achieving Selective Encapsulation for Theranostic Applications via a Facile Solvent Emulsion Method. Macromol Rapid Commun. 2018;:1800801 [Crossref]
71- Trucillo P, Campardelli R. Production of solid lipid nanoparticles with a supercritical fluid assisted process. The Journal of Supercritical Fluids. 2019;143:16 [Crossref]
72- Campani V, Salzano G, Lusa S, De Rosa G. Lipid Nanovectors to Deliver RNA Oligonucleotides in Cancer. Nanomaterials. 2016;6(7):131 [Crossref]
73- Zhou X, Huang L, Porter A, Vicente-Gomila J. Tracing the system transformations and innovation pathways of an emerging technology: Solid lipid nanoparticles. Technological Forecasting and Social Change. 2018; [Crossref]

Journal Info

Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 
Freq.: Quarterly

 

Quick link

Editorial Board

Permission

Platinum Open Access

(no submission or publication fees)

 

Powered by