Logo-apb
Adv Pharm Bull. 2015;5(3): 435-441. doi: 10.15171/apb.2015.059
PMID: 26504767        PMCID: PMC4616884

Short Communication

The Effect of Tween 20, 60, and 80 on Dissolution Behavior of Sprionolactone in Solid Dispersions Prepared by PEG 6000

Jafar Akbari 1,2 * , Majd Saeedi 1,2, Katayoun Morteza-Semnani 3, Hamid Reza Kelidari 2, Farshad Sadegh Moghanlou 1, Gity Zareh 1, Sohrab Rostamkolaei 1

Cited by CrossRef: 21


1- Fereig S, El-Zaafarany G, Arafa M, Abdel-Mottaleb M. Self-assembled tacrolimus-loaded lecithin-chitosan hybrid nanoparticles for in vivo management of psoriasis. International Journal of Pharmaceutics. 2021;608:121114 [Crossref]
2- Alrouhayyah R, F. Sheshko T, N. Suslina S, Aisha O. Solid Dispersions: An Effective Technology for Improving Dissolution Kinetics of Poorly Soluble Drugs. RJPT. 2023;:5701 [Crossref]
3- Yun T, Lee J, Bang K, Cho J, Kim K. A Quaternary Solid Dispersion System for Improving the Solubility of Olaparib. Solids. 2025;6(1):1 [Crossref]
4- Huang L, Hu W, Yue P, Liao Y, Chen H, Chen Y. Development and evaluation of Tween-80 modified breviscapine nanocrystals for enhanced oral absorption. Journal of Drug Delivery Science and Technology. 2025;107:106819 [Crossref]
5- Akakuru O, Xu C, Liu C, Li Z, Xing J, Pan C, Li Y, Nosike E, Zhang Z, Iqbal Z, Zheng J, Wu A. Metal-Free Organo-Theranostic Nanosystem with High Nitroxide Stability and Loading for Image-Guided Targeted Tumor Therapy. 2021;15(2):3079 [Crossref]
6- Ghataty D, Amer R, Wasfi R, Shamma R. Novel linezolid loaded bio-composite films as dressings for effective wound healing: experimental design, development, optimization, and antimicrobial activity. Drug Delivery. 2022;29(1):3168 [Crossref]
7- Putri R, Enggi C, Sulistiawati S, Burhanuddin H, Iskandar I, Saputra R, Rahman L, Sartini S, Rifai Y, Aswad M, Permana A. Development of itraconazole ocular delivery system using β-cyclodextrin complexation incorporated into dissolving microneedles for potential improvement treatment of fungal keratitis. Journal of Biomaterials Science, Polymer Edition. 2024;35(15):2315 [Crossref]
8- Choi J, Cho N, Kim D, Park J. Comparison of paclitaxel solid dispersion and polymeric micelles for improved oral bioavailability and in vitro anti-cancer effects. Materials Science and Engineering: C. 2019;100:247 [Crossref]
9- Hassan I, Gill M, Qureshi M, Rasool A, Islam A, Javaid M, Naqeeb Ur Rehman Qureshi M, Butt M. Sepiolite reinforced alginate-based hydrogels for drug delivery applications. 2026;13(8) [Crossref]
10- da Silva Bedin A, Janning J, José Tondo V, Galan V, Souza F, Leal Pieracio A, Santos G, Silva M, Lima I, Bunhak E. Tartaric acid pellets as a core for extended release of sildenafil citrate: development via solid dispersion and factorial design. Drug Development and Industrial Pharmacy. 2025;51(12):1828 [Crossref]
11- Khan L, Gul R, Sarfraz M, Bashir H, Shah N, Ahmad N, Hussain H, Mohsin S, Khan I, Shahzad Y, Nazir I, Amirzada M. Comparative Evaluation of Calcium Chloride and Polyethylene Glycol 400 on Drug Loading in Human Plasma-Derived Exosomes: Insights from BCS class II drug Spironolactone. J Pharm Innov. 2027;22(1) [Crossref]
12- Tubtimsri S, Weerapol Y. Improvement in Solubility and Absorption of Nifedipine Using Solid Solution: Correlations between Surface Free Energy and Drug Dissolution. Polymers. 2021;13(17):2963 [Crossref]
13- Omidvar M, Shabani M, Asadzadeh N, Jafari A, Fakhroueian Z, Biniaz-Delijani E. Efficiency of salinity-responsive ZnO/PEG nanocomposite on the immiscible fluid-fluid displacement and interface behavior in different formations. Journal of Molecular Liquids. 2025;428:127462 [Crossref]
14- Yu S, Piao H, Rejinold N, Jin G, Choi G, Choy J. Niclosamide–Clay Intercalate Coated with Nonionic Polymer for Enhanced Bioavailability toward COVID-19 Treatment. Polymers. 2021;13(7):1044 [Crossref]
15- Alhasso B, Ghori M, Conway B. Development of Nanoemulsions for Topical Application of Mupirocin. Pharmaceutics. 2023;15(2):378 [Crossref]
16- Bunch H, Park J, Choe H, Mostafiz M, Kim J, Lee K. Evaluating cytotoxicity of methyl benzoate in vitro. Heliyon. 2020;6(2):e03351 [Crossref]
17- Chaudhary N, Tripathi D, Rai A. A Technical Approach of Solubility Enhancement of Poorly Soluble Drugs: Liquisolid Technique. CDD. 2020;17(8):638 [Crossref]
18- Eh Suk V, Mohd. Latif F, Teo Y, Misran M. Development of nanostructured lipid carrier (NLC) assisted with polysorbate nonionic surfactants as a carrier for l-ascorbic acid and Gold Tri.E 30. J Food Sci Technol. 2020;57(9):3259 [Crossref]
19- Enwereuzo O, Akakuru O, Uwaoma R, Elemike E, Akakuru O. Self-assembled membrane-polymer nanoparticles of top-notch tissue tolerance for the treatment of gastroesophageal reflux disease. J Nanostruct Chem. 2021;11(4):707 [Crossref]
20- Khare P, Chogale M, Kakade P, Patravale V. Gellan gum–based in situ gelling ophthalmic nanosuspension of Posaconazole. Drug Deliv and Transl Res. 2022;12(12):2920 [Crossref]
21- Kakono C, Witika B, Makoni P, Walker R. Cationic nanocrystalline suspensions: a potential approach for nose to brain delivery of L-dopa in Parkinson’s therapy. Pharmaceutical Development and Technology. 2025;30(5):646 [Crossref]
22- Tubtimsri S, Weerapol Y. Development of Nifedipine Amorphous Solid Dispersion Composed of Surface-Active Agents. KEM. 2021;901:35 [Crossref]
23- Flynn J, Ryan A, Hudson S. Synergistic antimicrobial interactions of nisin A with biopolymers and solubilising agents for oral drug delivery. European Journal of Pharmaceutics and Biopharmaceutics. 2022;171:29 [Crossref]
24- Zhang X, Sudittapong B, Ward M. Catalytic reactions in a Co12 cuboctahedral cage arising from guest encapsulation and cage-based redox activation. Inorg Chem Front. 2023;10(4):1270 [Crossref]
25- Motamedi M, Madani F, Khosravani M, Adabi M. Preparation of surface-modified PLGA nanoparticles containing carbon quantum dots: insights from C6 cell line assays. Nanomedicine. 2025;20(12):1403 [Crossref]
26- Chiu Y, Zhang Z, Dziemidowicz K, Nikoletopoulos C, Angkawinitwong U, Chen J, Williams G. The Effect of Solvent Vapor Annealing on Drug-Loaded Electrospun Polymer Fibers. Pharmaceutics. 2020;12(2):139 [Crossref]
27- Li T, Fu X, Wang Y, Ouyang F, Liu L, Wen M, Zha G, Zhu L. Research on Ternary Solid Dispersions of Celecoxib with Surfactant: Preparation, Characterization, and Solubility Property. Russ J Gen Chem. 2024;94(1):170 [Crossref]
28- Rong H, Ren J, Wu Q, Zhu H, Dong C, Wang G. Repurposing niclosamide for COVID-19: Synergistic strategies of nanotechnology and novel materials to enhance antiviral efficacy. Microbial Pathogenesis. 2026;210:108169 [Crossref]
29- Hassan A, Soliman G. Rutin Nanocrystals with Enhanced Anti-Inflammatory Activity: Preparation and Ex Vivo/In Vivo Evaluation in an Inflammatory Rat Model. Pharmaceutics. 2022;14(12):2727 [Crossref]
30- Akakuru O, Iqbal M, Liu C, Xing J, Wei Z, Jiang Z, Fang Q, Yuan B, Nosike E, Xia J, Jin Y, Zheng J, Wu A. Self-assembled, biocompatible and biodegradable TEMPO-conjugated nanoparticles enable folate-targeted tumor magnetic resonance imaging. Applied Materials Today. 2020;18:100524 [Crossref]