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Adv Pharm Bull. 2016;6(2): 275-283. doi: 10.15171/apb.2016.039

PMID: 27478793 PMCID: PMC4961989

Short Communication

Anti-Inflammatory and Antioxidant Activity of Acalypha hispida Leaf and Analysis of its Major Bioactive Polyphenols by HPLC

Md. Afjalus Siraj ¹ * , Jamil A. Shilpi ², Md. Golam Hossain ², Shaikh Jamal Uddin ² * , Md. Khirul Islam ³, Ismet Ara Jahan ⁴, Hemayet Hossain ⁴

Cited by CrossRef: 13

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3- Morales Ramos J, Loja Herrera B, Rodríguez Alayo N, Benel Fernández D, Pérez Medina L, Loayza Estrada C, Mocarro Willis M, Sánchez Marín C. Hypoglycemic effect of the aqueous extract from Acalypha argomuelleri Briq. (Euphorbiaceae) 'Sweet stick' leaves in Rattus rattus var. albinus. F1000Res. 2025;14:800 [Crossref]

4- Howlader M, Siraj M, Dey S, Hira A, Ahmed A, Hossain M, Olajide O. Ficus hispidaBark Extract Prevents Nociception, Inflammation, and CNS Stimulation in Experimental Animal Model. Evidence-Based Complementary and Alternative Medicine. 2017;2017(1) [Crossref]

5- Gupta A, Singh A, Kumar R, Jamieson S, Pandey A, Bishayee A. Neuroprotective Potential of Ellagic Acid: A Critical Review. Advances in Nutrition. 2021;12(4):1211 [Crossref]

6- Sikder L, Khan M, Smrity S, Islam M, Khan S. Phytochemical and pharmacological investigation of the ethanol extract of Byttneria pilosa Roxb.. Clin Phytosci. 2022;8(1) [Crossref]

7- Çağlar H, Yılmaz Süslüer S, Kavaklı Ş, Gündüz C, Ertürk B, Özkınay F, Haydaroğlu A. Meme kanseri kök hücrelerinde elajik asit ile indüklenmiş miRNA’ların ifadesi ve elajik asidin apoptoz üzerine etkisi. 2017;56(4):183 [Crossref]

8- Shahjahan S, Ahmed K, Khanum S, Rupa A, Ethane N, Kundu P, Khatun M, Richi F, Sarker M, Alam S, Hossain M. Bioactivity and Phytochemical Characterization of Ceriops decandra (Griff.) Ding Hou. Leaves: HPLC‐DAD Profiling, Antioxidant, Antimicrobial, and Antidiarrheal Potentials. Chemistry & Biodiversity. 2025; [Crossref]

9- Islam M, Huq Atanu M, Siraj M, Acharyya R, Ahmed K, Dev S, Uddin S, Das A. Supplementation of syringic acid-rich Phrynium pubinerve leaves imparts protection against allergic inflammatory responses by downregulating iNOS, COX-2, and NF-κB expressions. Heliyon. 2023;9(2):e13343 [Crossref]

10- Nunes C, Barreto Arantes M, Menezes de Faria Pereira S, Leandro da Cruz L, de Souza Passos M, Pereira de Moraes L, Vieira I, Barros de Oliveira D. Plants as Sources of Anti-Inflammatory Agents. Molecules. 2020;25(16):3726 [Crossref]

11- Morales Ramos J, Loja Herrera B, Rodríguez Alayo N, Benel Fernández D, Pérez Medina L, Loayza Estrada C, Mocarro Willis M, Sánchez Marín C. Hypoglycemic effect of the aqueous extract from Acalypha argomuelleri Briq. (Euphorbiaceae) 'Sweet stick' leaves in Rattus rattus var. albinus. F1000Res. 2025;14:800 [Crossref]

12- Nasrollahzadeh M, Akbari R, Issaabadi Z, Sajadi S. Biosynthesis and characterization of Ag/MgO nanocomposite and its catalytic performance in the rapid treatment of environmental contaminants. Ceramics International. 2020;46(2):2093 [Crossref]

13- Alfei S, Zuccari G. Ellagic Acid: A Green Multi-Target Weapon That Reduces Oxidative Stress and Inflammation to Prevent and Improve the Condition of Alzheimer’s Disease. IJMS. 2025;26(2):844 [Crossref]

14- Alfei S, Marengo B, Zuccari G. Oxidative Stress, Antioxidant Capabilities, and Bioavailability: Ellagic Acid or Urolithins?. Antioxidants. 2020;9(8):707 [Crossref]

15- Morales Ramos J, Loja Herrera B, Rodríguez Alayo N, Benel Fernández D, Pérez Medina L, Loayza Estrada C, Mocarro Willis M, Sánchez Marín C. Hypoglycemic effect of the aqueous extract from Acalypha argomuelleri Briq. 'Sweet stick' leaves in Rattus rattus var. albinus. F1000Res. 2025;14:800 [Crossref]

16- Wang L, Qiao L, Liu Y, Li F, El-kott A, AlShehri M, Morsy K. Ultrasound assisted green synthesis of silver nanoparticles stabilized by chitosan polymers: Investigation of its therapeutic application in diarrhea. Journal of Science: Advanced Materials and Devices. 2024;9(3):100759 [Crossref]

17- Bolat E, Sarıtaş S, Duman H, Eker F, Akdaşçi E, Karav S, Witkowska A. Polyphenols: Secondary Metabolites with a Biological Impression. Nutrients. 2024;16(15):2550 [Crossref]

18- Wojtunik-Kulesza K, Niziński P, Krajewska A, Oniszczuk T, Combrzyński M, Oniszczuk A. Therapeutic Potential of Ellagic Acid in Liver Diseases. Molecules. 2025;30(12):2596 [Crossref]

19- Islam M, Atanu M, Siraj M, Acharyya R, Ahmed K, Dev S, Uddin S, Das A. Supplementation of Syringic Acid-Rich Phrynium Pubinerve Leaves Imparts Protection Against Allergic Inflammatory Responses by Downregulating iNOS, COX-2, and NF-κB Expressions. SSRN Journal. 2022; [Crossref]