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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2016;6(4): 617-625. doi: 10.15171/apb.2016.076
PMID: 28101469        PMCID: PMC5241420

Research Article

Concurrent Inflammation Augments Antimalarial Drugs-Induced Liver Injury in Rats

Hossein Niknahad 1,2, Reza Heidari 1 * , Roya Firuzi 2, Farzaneh Abazari 2, Maral Ramezani 2, Negar Azarpira 3, Massood Hosseinzadeh 4, Asma Najibi 2, Arastoo Saeedi 2

Cited by CrossRef: 13

1- Heidari R, Ahmadi F, Rahimi H, Azarpira N, Hosseinzadeh M, Najibi A, Niknahad H. Exacerbated liver injury of antithyroid drugs in endotoxin-treated mice. Drug and Chemical Toxicology. 2019;42(6):615 [Crossref]
2- Alhusayan R, Aldahmash B, El-Nagar D, Rady A, Ibrahim K, Alkahtani S, Saxena M. Butterbur (Petasites hybridus) Extract Ameliorates Hepatic Damage Induced by Ovalbumin in Mice. Oxidative Medicine and Cellular Longevity. 2020;2020:1 [Crossref]
3- BOUSTANY A, ONWUZO S, JOHNSON A, FARHAT D, NAJJAR M, ZEID H, ONWUZO C, ABU-HAMMOUR M, ABDEL-RAZEQ R, MOHAMED I, EREN B, ASAAD I. PREVALENCE AND RISK FACTORS ASSOCIATED WITH NON-ALCOHOLIC STEATOHEPATITIS IN PATIENTS WITH RHEUMATOID ARTHRITIS ON HYDROXYCHLOROQUINE: A POPULATION-BASED STUDY. Arq Gastroenterol. 2025;62 [Crossref]
4- Acquah S. Implications of COVID-19 Pandemic on Evolution of Diabetes in Malaria-Endemic African Region. Journal of Diabetes Research. 2020;2020:1 [Crossref]
5- Koroglu P, Ertik O, Us A, Us H, Çöremen M, Bulan O, Yanardag R. Protective Effect of Apocynin on Chloroquine and Gamma Radiation Induced Lipid Peroxidation, Antioxidant Enzymes Suppression and Histological Damage in Rat Testes. Biol Bull Russ Acad Sci. 2023;50(S4):S492 [Crossref]
6- Sousa I, Nogueira K, Pereira E, Oliveira R. Challenges in myeloperoxidase quantification: the inadequacies of current colorimetric approaches. Front Mol Biosci. 2025;12 [Crossref]
7- Takenaka Y, Tanaka T, Otaki S, Kanbe A, Morita T, Yokoi K, Sekiguchi S, Nakamura K, Satoh H, Tojo T, Uchiumi F, Kitabatake K, Aoki S, Tsukimoto M. Amodiaquine Analogs Are Potent Inhibitors of Interleukin-6 Production Induced by Activation of Toll-Like Receptors Recognizing Pathogen Nucleic Acids. Biological & Pharmaceutical Bulletin. 2024;47(12):2101 [Crossref]
8- Falcão M, Pamplona de Góes Cavalcanti L, Filgueiras Filho N, Antunes de Brito C. Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19. 2020;102(6):1214 [Crossref]
9- Delgado A, Stewart S, Urroz M, Rodríguez A, Borobia A, Akatbach-Bousaid I, González-Muñoz M, Ramírez E. Characterisation of Drug-Induced Liver Injury in Patients with COVID-19 Detected by a Proactive Pharmacovigilance Program from Laboratory Signals. JCM. 2021;10(19):4432 [Crossref]
10- Heidari R, Niknahad H, Sadeghi A, Mohammadi H, Ghanbarinejad V, Ommati M, Hosseini A, Azarpira N, Khodaei F, Farshad O, Rashidi E, Siavashpour A, Najibi A, Ahmadi A, Jamshidzadeh A. Betaine treatment protects liver through regulating mitochondrial function and counteracting oxidative stress in acute and chronic animal models of hepatic injury. Biomedicine & Pharmacotherapy. 2018;103:75 [Crossref]
11- Ommati M, Mobasheri A, Heidari R. Drug‐induced organ injury in coronavirus disease 2019 pharmacotherapy: Mechanisms and challenges in differential diagnosis and potential protective strategies. J Biochem & Molecular Tox. 2021;35(7) [Crossref]
12- Sun C, Yang X, Tang L, Chen J. A pharmacovigilance study on drug-induced liver injury associated with antibody-drug conjugates (ADCs) based on the food and drug administration adverse event reporting system. Expert Opinion on Drug Safety. 2024;23(8):1049 [Crossref]
13- Kazemi M, Ariapour A. Nutritional Dynamics of Iranian Pasture Flora: Implications for Animal Health and Productivity. Grass and Forage Science. 2025;80(2) [Crossref]
14- Heidari R, Arabnezhad M, Ommati M, Azarpira N, Ghodsimanesh E, Niknahad H. Boldine Supplementation Regulates Mitochondrial Function and Oxidative Stress in a Rat Model of Hepatotoxicity. Pharm Sci. 2019;25(1):1 [Crossref]
15- Brito C, Barros F, Lopes E. Mechanisms and consequences of COVID-19 associated liver injury: What can we affirm?. WJH. 2020;12(8):413 [Crossref]
16- Roth R, Ganey P. What have we learned from animal models of idiosyncratic, drug-induced liver injury?. Expert Opinion on Drug Metabolism & Toxicology. 2020;16(6):475 [Crossref]
17- Chen D, Pham C, Kaur M, Yip K. Hydroxychloroquine-Induced Hepatotoxicity in Systemic Lupus Erythematous: A Case Report and Literature Review. 2025; [Crossref]
18- Choaib A, Issa E, El Choueiry F, Eldin J, Shbaklo K, Alhajj M, Sawaya R, Assi G, Nader M, Chatila R, Faour W. SARS-CoV-2-mediated liver injury: pathophysiology and mechanisms of disease. Inflamm Res. 2023;72(2):301 [Crossref]