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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2015;5(2): 217-222. doi: 10.15171/apb.2015.030
PMID: 26236660        PMCID: PMC4517081

Original Research

Evaluating the Anti-nociceptive and Anti-inflammatory Effects of Ketotifen and Fexofenadine in Rats

Mahdieh Anoush 1,2 * , Mohammad Reza Mohammad Khani 1

Cited by CrossRef: 11

1- Habibi Asl B, Fallahi S, Bohlouli S, Soltani Zangbar H, Eteraf-Oskouei T. Prevention of morphine dependence with a combination of ketotifen and l-carnitine in mice: a new potential therapeutic approach. 2025; [Crossref]
2- Meloto C, Ingelmo P, Perez E, Pitt R, González Cárdenas V, Mohamed N, Sotocinal S, Bourassa V, Lima L, Ribeiro-da-Silva A, Mogil J, Diatchenko L. Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice. PR9. 2021;6(2):e902 [Crossref]
3- El-fatatry B, El-Haggar S, Ibrahim O, Shalaby K. Repurposing fexofenadine as a promising candidate for diabetic kidney disease: randomized clinical trial. Int Urol Nephrol. 2023;56(4):1395 [Crossref]
4- Abdelzaher W, AboBakr Ali A, El-Tahawy N. Mast cell stabilizer modulates Sirt1/Nrf2/TNF pathway and inhibits oxidative stress, inflammation, and apoptosis in rat model of cyclophosphamide hepatotoxicity. Immunopharmacology and Immunotoxicology. 2020;42(2):101 [Crossref]
5- Kirkpatrick D, McEntire D, Smith T, Dueck N, Kerfeld M, Hambsch Z, Nelson T, Reisbig M, Agrawal D. Transmission pathways and mediators as the basis for clinical pharmacology of pain. Expert Review of Clinical Pharmacology. 2016;9(10):1363 [Crossref]
6- SAHU N, LARIYA N. pH-RESPONSIVE EUDRAGIT® S-100 COATED CHITOSAN NANOPARTICLES FOR TARGETED CURCUMIN DELIVERY IN ULCERATIVE COLITIS: FORMULATION AND OPTIMIZATION. Int J App Pharm. 2025;:252 [Crossref]
7- Khalilzadeh E, Azarpey F, Hazrati R, Vafaei Saiah G. Evaluation of different classes of histamine H1 and H2 receptor antagonist effects on neuropathic nociceptive behavior following tibial nerve transection in rats. European Journal of Pharmacology. 2018;834:221 [Crossref]
8- de Souza S, Laumet S, Hua H, Inyang K, Sim J, Folger J, Moeser A, Laumet G. Mast cell–derived chymases are essential for the resolution of inflammatory pain in mice. Pain. 2025;166(8):1811 [Crossref]
9- Lagard C, Vodovar D, Chevillard L, Callebert J, Caillé F, Pottier G, Liang H, Risède P, Tournier N, Mégarbane B. Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat. Pharmaceuticals. 2022;15(10):1254 [Crossref]
10- Kim Y, Hussain Z, Lee Y, Park H. Altered Intestinal Permeability and Drug Repositioning in a Post-operative Ileus Guinea Pig Model. J Neurogastroenterol Motil. 2021;27(4):639 [Crossref]
11- Liao C, Booker R, Brosseau J, Chen Z, Mo J, Tchegnon E, Wang Y, Clapp D, Le L. Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis. 2018;128(7):2848 [Crossref]
12- Cronin S, Rao S, Tejada M, Turnes B, Licht-Mayer S, Omura T, Brenneis C, Jacobs E, Barrett L, Latremoliere A, Andrews N, Channon K, Latini A, Arvanites A, Davidow L, Costigan M, Rubin L, Penninger J, Woolf C. Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer. Sci Transl Med. 2022;14(660) [Crossref]
13- Awad-Igbaria Y, Dadon S, Shamir A, Livoff A, Shlapobersky M, Bornstein J, Palzur E. Characterization of Early Inflammatory Events Leading to Provoked Vulvodynia Development in Rats. JIR. 2022;Volume 15:3901 [Crossref]